Rabbit anti-Human SLC2A2 Polyclonal Antibody | anti-SLC2A2 antibody

SLC2A2 Conjugated Antibody

Cat. Num. AAA9447351

• Gene Names: SLC2A2; GLUT2
• Reactivity: Human
• Applications: Most Applications
• Synonyms: SLC2A2; Polyclonal Antibody; SLC2A2 Conjugated Antibody; GLUT3; anti-SLC2A2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total SLC2A2 protein.
• Form/Format: 0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide

• Applicable Applications for anti-SLC2A2 antibody: Most Applications
• Application Notes: Suggested Dilution:; AF350 conjugated: most applications: 1:50-1:250; AF405 conjugated: most applications: 1:50-1:250; AF488 conjugated: most applications: 1:50-1:250; AF555 conjugated: most applications: 1:50-1:250; AF594 conjugated: most applications: 1:50-1:250; AF647 conjugated: most applications: 1:50-1:250; AF680 conjugated: most applications: 1:50-1:250; AF750 conjugated: most applications: 1:50-1:250; Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1:50-1:1000
• Immunogen: Synthetic peptide corresponding to a region derived from internal residues of human solute carrier family 2 (facilitated glucose transporter), member 3
• Conjugation: Biotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750
• Excitation Emission: AF350: 346nm/442nm
• Preparation and Storage: Store at 4 degree C for 6 months.

Related Product Information for anti-SLC2A2 antibody

Glucose transporter 3 (orGLUT3), also known as solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3) is a protein that in humans is encoded by the SLC2A3 gene. GLUT3 facilitates the transport ofglucose across the plasma membranes of mammalian cells. GLUT3 is most known for its specific expression in neurons and has originally been designated as the neuronal GLUT. GLUT3 has been studied in other cell types with specific glucose requirements, including sperm, preimplantation embryos, circulating white blood cells and carcinoma cell lines. GLUT3 has both a higher affinity for glucose and at least a fivefold greater transport capacity than GLUT1, GLUT2 and GLUT4, which is particularly significant for its role in neuronal glucose transport, where ambient glucose levels are fivefold lower than in serum.

NCBI and Uniprot Product Information

• NCBI GI #: 4557851
• NCBI GeneID: 6514
• NCBI Accession #: NP_000331
• NCBI GenBank Nucleotide #: NM_000340
• UniProt Accession #: P11168
• Molecular Weight: 58kDa
• NCBI Official Full Name: solute carrier family 2, facilitated glucose transporter member 2 isoform 1
• NCBI Official Synonym Full Names: solute carrier family 2 member 2
• NCBI Official Symbol: SLC2A2
• NCBI Official Synonym Symbols: GLUT2
• NCBI Protein Information: solute carrier family 2, facilitated glucose transporter member 2
• UniProt Protein Name: Solute carrier family 2, facilitated glucose transporter member 2
• Protein Family: Solute carrier family
• UniProt Gene Name: SLC2A2
• UniProt Synonym Gene Names: GLUT2; GLUT-2
• UniProt Entry Name: GTR2_HUMAN

NCBI Description

This gene encodes an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. The encoded protein mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. Mutations in this gene are associated with susceptibility to diseases, including Fanconi-Bickel syndrome and noninsulin-dependent diabetes mellitus (NIDDM). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

Uniprot Description

GLUT2: an integral membrane facilitative glucose transporter. One of 13 members of the human equilibrative glucose transport protein family. Present at high levels in the plasma membrane of pancreatic b-cells where it initiates the first step in glucose-stimulated insulin secretion, a glucose metabolism-dependent signaling mechanism. May mediate the bidirectional transfer of glucose across the plasma membrane of hepatocytes. May also participate with the Na( +2)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney. Required for glucose sensitivity in the hypothalamus and brain stem. Involved in the control of food intake and stimulation of glucose uptake by peripheral tissues.

Protein type: Transporter, SLC family; Transporter; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 3q26.1-q26.2

Cellular Component: apical plasma membrane; basolateral plasma membrane; brush border membrane; cytosol; endosome; integral to plasma membrane; intercellular junction; membrane; plasma membrane

Molecular Function: D-glucose transmembrane transporter activity; dehydroascorbic acid transporter activity; glucose transmembrane transporter activity; hexose transmembrane transporter activity; insulin receptor binding

Biological Process: carbohydrate metabolic process; carbohydrate utilization; fructose transport; glucose transport; hexose transport; regulation of insulin secretion; response to glucose stimulus; response to peptide hormone stimulus

Disease: Diabetes Mellitus, Noninsulin-dependent; Fanconi-bickel Syndrome