anti-Human SLC2A2 Polyclonal Antibody | anti-SLC2A2 antibody

Anti-SLC2A2 Antibody

Cat. Num. AAA178390

• Gene Names: SLC2A2; GLUT2
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry
• Purity: Immunogen Affinity Purified
• Synonyms: SLC2A2; Polyclonal Antibody; Anti-SLC2A2 Antibody; Solute carrier family 2; facilitated glucose transporter member 2; liver; Glucose Transporter 2; Glucose Transporter GLUT2; Glucose transporter type 2; Glucose transporter type 2 liver; Glucose transporter; liver/islet; GLUT-2; GLUT2; GTR2_HUMAN; GTT2; Solute carrier family 2 (facilitated glucose transporter) member 2; Solute carrier family 2 facilitated glucose transporter member 2; solute carrier family 2 (facilitated glucose transporter); member 2; anti-SLC2A2 antibody

• Reactivity: Human
• Clonality: Polyclonal
• Purity/Purification: Immunogen Affinity Purified
• Form/Format: Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
• Sequence Length: 524

• Applicable Applications for anti-SLC2A2 antibody: Western Blot (WB), Immunohistochemistry (IHC) Paraffin
• Application Notes: Western Blot Concentration: 0.1-0.5ug/ml; Immunohistochemistry (IHC) Paraffin Concentration: 0.5-1ug/ml
• Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human SLC2A2 (486-514aa ETKGKSFEEIAAEFQKKSGSAHRPKAAVE), different from the related mouse sequence by five amino acids, and from the related rat sequence by seven amino acids.
• Ig Type: Rabbit IgG
• Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
• Preparation and Storage: At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquoted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Western Blot (WB)

(Anti- SLC2A2 Picoband antibody, MBS178390, Western blottingAll lanes: Anti SLC2A2 (MBS178390) at 0.5ug/mlLane 1: PANC Whole Cell Lysate at 40ugLane 2: A549 Whole Cell Lysate at 40ugLane 3: HT1080 Whole Cell Lysate at 40ugPredicted bind size: 57KDObserved bind size: 50KD )

Immunohistochemistry (IHC)

(Anti- SLC2A2 Picoband antibody, MBS178390, IHC(P)IHC(P): Human Liver Cancer Tissue )

Related Product Information for anti-SLC2A2 antibody

Description: Rabbit IgG polyclonal antibody for Solute carrier family 2, facilitated glucose transporter member 2(SLC2A2) detection. Tested with WB, IHC-P in Human.

Background: SLC2A2, also known as Glucose transporter 2 (GLUT2), is a transmembrane carrier protein that enables protein facilitatedglucose movement across cell membranes. This gene encodes an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. The encoded protein mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. Mutations in this gene are associated with susceptibility to diseases, including Fanconi-Bickel syndrome and noninsulin-dependent diabetes mellitus (NIDDM). Alternative splicing results in multiple transcript variants of this gene.

References

1. Froguel P, Zouali H, Sun F, Velho G, Fukumoto H, Passa P, Cohen D (July 1991)."CA repeat polymorphism in the glucose transporter GLUT 2 gene". Nucleic Acids Res. 19 (13): 3754. 2. Santer R, Groth S, Kinner M, Dombrowski A, Berry GT, Brodehl J, Leonard JV, Moses S, Norgren S, Skovby F, Schneppenheim R, Steinmann B, Schaub J (January 2002). "The mutation spectrum of the facilitative glucose transporter gene SLC2A2 (GLUT2) in patients with Fanconi-Bickel syndrome".Hum. Genet. 110 (1): 21-9. 3. Uldry M, Ibberson M, Hosokawa M, Thorens B (July 2002). "GLUT2 is a high affinity glucosamine transporter". FEBS Lett. 524(1-3): 199-203.

NCBI and Uniprot Product Information

• NCBI GI #: 4557851
• NCBI GeneID: 6514
• NCBI Accession #: NP_000331.1
• NCBI GenBank Nucleotide #: NM_000340.1
• UniProt Accession #: P11168; Q9UCW9; A8K481; B2R936; B7Z547; F8W8V8
• Molecular Weight: 44,702 Da
• NCBI Official Full Name: solute carrier family 2, facilitated glucose transporter member 2 isoform 1
• NCBI Official Synonym Full Names: solute carrier family 2 member 2
• NCBI Official Symbol: SLC2A2
• NCBI Official Synonym Symbols: GLUT2
• NCBI Protein Information: solute carrier family 2, facilitated glucose transporter member 2
• UniProt Protein Name: Solute carrier family 2, facilitated glucose transporter member 2
• Protein Family: Solute carrier family
• UniProt Gene Name: SLC2A2
• UniProt Synonym Gene Names: GLUT2; GLUT-2
• UniProt Entry Name: GTR2_HUMAN

NCBI Description

This gene encodes an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. The encoded protein mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. Mutations in this gene are associated with susceptibility to diseases, including Fanconi-Bickel syndrome and noninsulin-dependent diabetes mellitus (NIDDM). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

Uniprot Description

GLUT2: an integral membrane facilitative glucose transporter. One of 13 members of the human equilibrative glucose transport protein family. Present at high levels in the plasma membrane of pancreatic b-cells where it initiates the first step in glucose-stimulated insulin secretion, a glucose metabolism-dependent signaling mechanism. May mediate the bidirectional transfer of glucose across the plasma membrane of hepatocytes. May also participate with the Na( +2)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney. Required for glucose sensitivity in the hypothalamus and brain stem. Involved in the control of food intake and stimulation of glucose uptake by peripheral tissues.

Protein type: Transporter, SLC family; Transporter; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 3q26.1-q26.2

Cellular Component: apical plasma membrane; basolateral plasma membrane; brush border membrane; cytosol; endosome; integral to plasma membrane; intercellular junction; membrane; plasma membrane

Molecular Function: D-glucose transmembrane transporter activity; dehydroascorbic acid transporter activity; glucose transmembrane transporter activity; hexose transmembrane transporter activity; insulin receptor binding

Biological Process: carbohydrate metabolic process; carbohydrate utilization; fructose transport; glucose transport; hexose transport; regulation of insulin secretion; response to glucose stimulus; response to peptide hormone stimulus

Disease: Diabetes Mellitus, Noninsulin-dependent; Fanconi-bickel Syndrome