Rabbit anti-Human SLC23A1 Polyclonal Antibody | anti-SLC23A1 antibody

SLC23A1, NT (SLC23A1, SVCT1, YSPL3, Solute carrier family 23 member 1, Na(+)/L-ascorbic acid transporter 1, Sodium-dependent vitamin C transporter 1, Yolk sac permease-like molecule 3) (FITC)

Cat. Num. AAA6348190

• Gene Names: SLC23A1; SVCT1; YSPL3; SLC23A2
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: SLC23A1; Polyclonal Antibody; NT (SLC23A1; SVCT1; YSPL3; Solute carrier family 23 member 1; Na(+)/L-ascorbic acid transporter 1; Sodium-dependent vitamin C transporter 1; Yolk sac permease-like molecule 3) (FITC); Yolk sac permease-like molecule 3; anti-SLC23A1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-SLC23A1 antibody: Immunohistochemistry (IHC), FLISA, Western Blot (WB)
• Application Notes: IHC: 1:10-50; FLISA: 1:1,000; WB: 1:100-500; Applications are based on unconjugated antibody.
• Immunogen: SLC23A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human SLC23A1.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(SLC23A1 Antibody (N-term) western blot analysis in HepG2(lane 1),NCI-H292(lane 2) cell line lysates (35ug/lane).This demonstrates the SLC23A1 antibody detected the SLC23A1 protein (arrow).)

Immunohistochemistry (IHC)

(SLC23A1 Antibdy (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SLC23A1 Antibdy (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)

Related Product Information for anti-SLC23A1 antibody

The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two transporters. The encoded protein is active in bulk vitamin C transport involving epithelial surfaces. Previously, this gene had an official symbol of SLC23A2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

Product Categories/Family for anti-SLC23A1 antibody

Antibodies; Ion Channel

References

Timpson, N.J., et al. Am. J. Clin. Nutr. 92(2):375-382(2010). Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010). Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010). Michels, A.J., et al. Am. J. Physiol., Cell Physiol. 297 (5), C1220-C1227 (2009): Cahill, L.E., et al. J Nutrigenet Nutrigenomics 2(6):292-301(2009).

NCBI and Uniprot Product Information

• NCBI GI #: 44680145
• NCBI GeneID: 9963
• NCBI Accession #: NP_005838.3
• NCBI GenBank Nucleotide #: NM_005847.4
• UniProt Accession #: Q9UHI7; O95191; Q8WWB6; Q9UGH4; Q9UI39
• Molecular Weight: 64,831 Da
• NCBI Official Full Name: solute carrier family 23 member 1 isoform a
• NCBI Official Synonym Full Names: solute carrier family 23 (ascorbic acid transporter), member 1
• NCBI Official Symbol: SLC23A1
• NCBI Official Synonym Symbols: SVCT1; YSPL3; SLC23A2
• NCBI Protein Information: solute carrier family 23 member 1; hSVCT1; yolk sac permease-like molecule 3; Na(+)/L-ascorbic acid transporter 1; sodium-dependent vitamin C transporter 1; sodium-dependent vitamin C transporter-1; solute carrier family 23 (nucleobase transporters), memb
• UniProt Protein Name: Solute carrier family 23 member 1
• Protein Family: Solute carrier family
• UniProt Gene Name: SLC23A1
• UniProt Synonym Gene Names: SVCT1; YSPL3; hSVCT1
• UniProt Entry Name: S23A1_HUMAN

NCBI Description

The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two transporters. The encoded protein is active in bulk vitamin C transport involving epithelial surfaces. Previously, this gene had an official symbol of SLC23A2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

Uniprot Description

SLC23A1: Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate. Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter; Membrane protein, multi-pass; Transporter, SLC family; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q31.2

Cellular Component: membrane; integral to plasma membrane; apical plasma membrane; cytoplasm; basal plasma membrane; plasma membrane; intracellular organelle; brush border

Molecular Function: L-ascorbate:sodium symporter activity; protein binding; dehydroascorbic acid transporter activity; sodium ion transmembrane transporter activity; L-ascorbic acid transporter activity; nucleobase transmembrane transporter activity

Biological Process: vitamin metabolic process; response to toxin; sodium ion transport; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; L-ascorbic acid metabolic process; nucleobase transport; brain development; water-soluble vitamin metabolic process; lung development; L-ascorbic acid transport