Rabbit SLC22A8 Polyclonal Antibody | anti-SLC22A8 antibody

SLC22A8 Polyclonal Antibody

Cat. Num. AAA2525130

• Gene Names: SLC22A8; OAT3
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: SLC22A8; Polyclonal Antibody; SLC22A8 Polyclonal Antibody; OAT3; anti-SLC22A8 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 2.1mg/mL (varies by lot)
• Sequence Length: 419

• Applicable Applications for anti-SLC22A8 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:50-1:200
• Immunogen: Synthetic peptide of human SLC22A8
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using SLC22A8 Polyclonal Antibody at dilution 1:70)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using SLC22A8 Polyclonal Antibody at dilution 1:70)

Related Product Information for anti-SLC22A8 antibody

This gene encodes a protein involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 296080734
• NCBI GeneID: 9376
• NCBI Accession #: NP_001171665.1
• NCBI GenBank Nucleotide #: NM_001184736.1
• Molecular Weight: 49,821 Da
• NCBI Official Full Name: solute carrier family 22 member 8 isoform 3
• NCBI Official Synonym Full Names: solute carrier family 22 (organic anion transporter), member 8
• NCBI Official Symbol: SLC22A8
• NCBI Official Synonym Symbols: OAT3
• NCBI Protein Information: solute carrier family 22 member 8; hOAT3; organic anion transporter 3
• UniProt Protein Name: Solute carrier family 22 member 8
• Protein Family: Solute carrier family
• UniProt Gene Name: SLC22A8
• UniProt Synonym Gene Names: OAT3; hOAT3
• UniProt Entry Name: S22A8_HUMAN

NCBI Description

This gene encodes a protein involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, May 2010]

Uniprot Description

SLC22A8: Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone- 3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA). Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Transporter, SLC family; Membrane protein, integral; Transporter

Chromosomal Location of Human Ortholog: 11q11

Cellular Component: basolateral plasma membrane; plasma membrane; integral to membrane

Molecular Function: protein kinase C binding; inorganic anion exchanger activity; organic anion transmembrane transporter activity; quaternary ammonium group transmembrane transporter activity

Biological Process: quaternary ammonium group transport; response to toxin; response to methotrexate; transmembrane transport