Rabbit anti-Human SLC22A2 Polyclonal Antibody | anti-SLC22A2 antibody

SLC22A2 Antibody (N-term)

Cat. Num. AAA9216797

• Gene Names: SLC22A2; OCT2
• Reactivity: Human
• Applications: Western Blot
• Synonyms: SLC22A2; Polyclonal Antibody; SLC22A2 Antibody (N-term); Purified Rabbit Polyclonal Antibody (Pab); Solute carrier family 22 member 2; Organic cation transporter 2; hOCT2; OCT2; anti-SLC22A2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Ig
• Specificity: This SLC22A2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 57-89 amino acids from the N-terminal region of human SLC22A2.
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Sequence Length: 555

• Applicable Applications for anti-SLC22A2 antibody: Western Blot (WB)
• Application Notes: WB ~~ 1:2000
• Antigen Source: Human
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(All lanes : Anti-SLC22A2 Antibody (N-term) at 1:2000 dilutionLane 1: 293T/17 whole cell lysateLane 2: A431 whole cell lysateLane 3: HepG2 whole cell lysateLane 4: Jurkat whole cell lysateLane 5: Raji whole cell lysateLysates/proteins at 20 ug per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.Predicted band size : 63 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)

Related Product Information for anti-SLC22A2 antibody

Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity.

Product Categories/Family for anti-SLC22A2 antibody

Crown Antibodies; Signal Transduction

References

Gorboulev V.,et al.DNA Cell Biol. 16:871-881(1997). Urakami Y.,et al.J. Am. Soc. Nephrol. 13:1703-1710(2002). Ota T.,et al.Nat. Genet. 36:40-45(2004). Mungall A.J.,et al.Nature 425:805-811(2003). Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

NCBI and Uniprot Product Information

• NCBI GI #: 302148518
• NCBI GeneID: 6582
• NCBI Accession #: NP_003049.2
• NCBI GenBank Nucleotide #: NM_003058.3
• UniProt Accession #: O15244; Q5T7Q6; Q6PIQ8; Q8NG62; Q9NQB9
• Molecular Weight: 62581
• NCBI Official Full Name: solute carrier family 22 member 2
• NCBI Official Synonym Full Names: solute carrier family 22 (organic cation transporter), member 2
• NCBI Official Symbol: SLC22A2
• NCBI Official Synonym Symbols: OCT2
• NCBI Protein Information: solute carrier family 22 member 2
• UniProt Protein Name: Solute carrier family 22 member 2
• Protein Family: Solute carrier family
• UniProt Gene Name: SLC22A2
• UniProt Synonym Gene Names: OCT2; hOCT2
• UniProt Entry Name: S22A2_HUMAN

NCBI Description

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption. [provided by RefSeq, Jul 2008]

Uniprot Description

SLC22A2: Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Transporter; Membrane protein, integral; Transporter, SLC family

Chromosomal Location of Human Ortholog: 6q25.3

Cellular Component: membrane; integral to plasma membrane; plasma membrane

Molecular Function: organic cation transmembrane transporter activity; dopamine transmembrane transporter activity; quaternary ammonium group transmembrane transporter activity; choline transmembrane transporter activity

Biological Process: synaptic transmission; dopamine transport; organic cation transport; quaternary ammonium group transport; neurotransmitter secretion; multidrug transport; choline transport; body fluid secretion; transmembrane transport; neurotransmitter biosynthetic process