Goat anti-Human SLC17A7 Polyclonal Antibody | anti-SLC17A7 antibody

SLC17A7 (Vesicular Glutamate Transporter 1, VGluT1, Brain-specific Na(+)-dependent Inorganic Phosphate Cotransporter, Solute Carrier Family 17 Member 7, BNPI, VGLUT1)

Cat. Num. AAA644286

• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: SLC17A7; Polyclonal Antibody; SLC17A7 (Vesicular Glutamate Transporter 1; VGluT1; Brain-specific Na(+)-dependent Inorganic Phosphate Cotransporter; Solute Carrier Family 17 Member 7; BNPI; VGLUT1); Anti -SLC17A7 (Vesicular Glutamate Transporter 1; anti-SLC17A7 antibody

• Host: Goat
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes human SLC17A7.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.

• Applicable Applications for anti-SLC17A7 antibody: Immunohistochemistry (IHC)
• Application Notes: Suitable for use in Immunohistochemistry.; Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 3.75ug/ml
• Immunogen: Synthetic peptide corresponding to HDQLAGSDDSEMED from the internal region of human VGluT1.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunohistochemistry (IHC)

(Brain, cortex, Human: Formalin-Fixed, Paraffin-Embedded (FFPE))

Related Product Information for anti-SLC17A7 antibody

Glutamate is the main excitatory neurotransmitter in the brain. To date five glutamate Transporters have been cloned: GLAST (EAAT1), GLT1 (EAAT2), EAAC1 (EAAT3), EAAT4, and EAAT5. These transporters are believed to be critical in reducing potentially toxic extracellular concentration of glutamate by rapid uptake into nerve terminals and glial cells. Most recently, vesicular type transporters for glutamate, termed VGLUTs (VGLUT1/BNPI, VGLUT2/DNPI, and EAT-4), have been cloned and characterized that are related to phosphate transporters. Although neurons exhibit Na-dependent Pi transport, the biological role of Pi uptake is not clear. Proximal tubules in the kidney reabsorb Pi in the glomeruli by the action of a group of phosphate transporters (Type 1-NaPi related, type 2-NaPi-2 related, and type 3-viral receptor-related. These receptors show weak (~20% identity) between various subtypes. A distinct type of brain specific Na+-dependent phosphate (Pi) transporter (BNPI), originally characterized as a plasma membrane transporter has been localized in a subset of glutamatergic neurons (amygdla,cereberal cortex, and hippocmaplus) and identified as VGLUT1 (rat and human 560 aa; ~60kD, ~30% homology with type-1 Pi-transporters & ~75-80% homology with VGLUT2). Interestingly, a sequence induced by subtoxic levels of NMDA in cerebelar granules also belongs to this family of transporters. BNPI/VGLUT1 is expression is restricted to the brain, where it is predominantly located in synaptic vesicles. VGLUT1 shows strong sequence homology (~48%) to EAT-4, a C. elegans protein that appears to have specific presynaptioc role in glutamtergic transmission.

Product Categories/Family for anti-SLC17A7 antibody

Antibodies; Abs to Glucose Transporters

NCBI and Uniprot Product Information

• NCBI GI #: 133778129
• NCBI GeneID: 518849
• UniProt Accession #: A4FV52
• Molecular Weight: 61,651 Da
• NCBI Official Full Name: SLC17A7 protein
• NCBI Official Symbol: SLC17A7
• NCBI Protein Information: vesicular glutamate transporter 1; VGluT1; solute carrier family 17 member 7; solute carrier family 17, member 7
• UniProt Protein Name: Vesicular glutamate transporter 1
• Protein Family: Vesicular glutamate transporter
• UniProt Gene Name: SLC17A7
• UniProt Synonym Gene Names: VGLUT1; VGluT1
• UniProt Entry Name: VGLU1_BOVIN

Uniprot Description

Function: Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate

By similarity.

Subcellular location: Cytoplasmic vesicle › secretory vesicle › synaptic vesicle membrane

By similarity. Membrane; Multi-pass membrane protein

Potential. Cell junction › synapse › synaptosome

By similarity.

Sequence similarities: Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.