Rabbit anti-Human, Mouse SLC17A3 Polyclonal Antibody | anti-SLC17A3 antibody

SLC17A3 Antibody

Cat. Num. AAA9630850

• Gene Names: SLC17A3; NPT4
• Reactivity: Human, Mouse
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: SLC17A3; Polyclonal Antibody; SLC17A3 Antibody; Na(+)/PI cotransporter 4; NPT4; Sodium dependent phosphate transport protein 3; Sodium phosphate cotransporter 3; Sodium-dependent phosphate transport protein 4; Sodium/phosphate cotransporter 4; Solute carrier family 17 sodium phosphate member 3; anti-SLC17A3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: SLC17A3 Antibody detects endogenous levels of SLC17A3.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-SLC17A3 antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from human SLC17A3.
• Conjugation: Unconjugated
• Similarity: Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.
• Tissue Specificity: Expressed in the liver and kidney. It is detected in proximal tubules in renal cortex as well as some tubules and glomeruli, with highest expression at the apical side of proximal tubules (at protein level).
• Function: voltage-driven, multispecific, organic anion transporter able to transport para-aminohippurate (PAH), estrone sulfate, estradiol-17-beta-glucuronide, bumetanide, and ochratoxin A. Isoform 2 functions as urate efflux transporter on the apical side of renal proximal tubule and is likely to act as an exit path for organic anionic drugs as well as urate in vivo. May be involved in actively transporting phosphate into cells via Na(+) cotransport.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-SLC17A3 antibody

Endoplasmic reticulum membrane; Multi-pass membrane protein; Cell membrane; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 148743791
• NCBI GeneID: 10786
• NCBI Accession #: NP_001091956.1
• NCBI GenBank Nucleotide #: NM_001098486.1
• UniProt Accession #: O00476; Q8WWC7; Q9H533; B7WNJ5; B7Z511
• Molecular Weight: 46,106 Da
• NCBI Official Full Name: sodium-dependent phosphate transport protein 4 isoform a
• NCBI Official Synonym Full Names: solute carrier family 17 (organic anion transporter), member 3
• NCBI Official Symbol: SLC17A3
• NCBI Official Synonym Symbols: NPT4
• NCBI Protein Information: sodium-dependent phosphate transport protein 4; Na(+)/PI cotransporter 4; sodium/phosphate cotransporter 4; solute carrier family 17 (sodium phosphate), member 3
• UniProt Protein Name: Sodium-dependent phosphate transport protein 4
• Protein Family: Sodium-dependent phosphate transport protein
• UniProt Gene Name: SLC17A3
• UniProt Synonym Gene Names: NPT4
• UniProt Entry Name: NPT4_HUMAN

NCBI Description

The protein encoded by this gene is a voltage-driven transporter that excretes intracellular urate and organic anions from the blood into renal tubule cells. Two transcript variants encoding different isoforms have been found for this gene. The longer isoform is a plasma membrane protein with transporter activity while the shorter isoform localizes to the endoplasmic reticulum. [provided by RefSeq, Aug 2012]

Uniprot Description

Function: Isoform 2: voltage-driven, multispecific, organic anion transporter able to transport para-aminohippurate (PAH), estrone sulfate, estradiol-17-beta-glucuronide, bumetanide, and ochratoxin A. Isoform 2 functions as urate efflux transporter on the apical side of renal proximal tubule and is likely to act as an exit path for organic anionic drugs as well as urate in vivo. May be involved in actively transporting phosphate into cells via Na+ cotransport. Ref.7

Subcellular location: Isoform 1: Endoplasmic reticulum membrane; Multi-pass membrane protein Ref.6 Ref.7. Isoform 2: Cell membrane; Multi-pass membrane protein Ref.6 Ref.7.

Tissue specificity: Expressed in the liver and kidney. It is detected in proximal tubules in renal cortex as well as some tubules and glomeruli, with highest expression at the apical side of proximal tubules (at protein level). Ref.1 Ref.7

Polymorphism: Genetic variations in SLC17A3 influence the variance in serum uric acid concentrations and define the serum uric acid concentration quantitative trait locus 4 (UAQTL4) [

MIM:612671]. Excess serum accumulation of uric acid can lead to the development of gout, a common disorder characterized by tissue deposition of monosodium urate crystals as a consequence of hyperuricemia.

Sequence similarities: Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.

Sequence caution: The sequence AAB53423.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.