Rabbit anti-Human SKAP2 Polyclonal Antibody | anti-SKAP2 antibody

SKAP2, ID (SKAP2, PRAP, RA70, SAPS, SCAP2, SKAP55R, Src kinase-associated phosphoprotein 2, Pyk2/RAFTK-associated protein, Retinoic acid-induced protein 70, SKAP55 homolog, Src family-associated phosphoprotein 2, Src kinase-associated phosphoprotein 55-re

Cat. Num. AAA6347933

• Gene Names: SKAP2; PRAP; RA70; SAPS; SCAP2; SKAP55R; SKAP-HOM
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: SKAP2; Polyclonal Antibody; ID (SKAP2; PRAP; RA70; SAPS; SCAP2; SKAP55R; Src kinase-associated phosphoprotein 2; Pyk2/RAFTK-associated protein; Retinoic acid-induced protein 70; SKAP55 homolog; Src family-associated phosphoprotein 2; Src kinase-associated phosphoprotein 55-re; Src kinase-associated phosphoprotein 55-related protein; Src-associated adapter protein with PH and SH3 domains; anti-SKAP2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-SKAP2 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: SKAP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 136-165 amino acids from the Central region of human SKAP2.
• Conjugate: PE
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(SKAP2 Antibody (Center) western blot analysis in U937 cell line lysates (35ug/lane).This demonstrates the SKAP2 antibody detected the SKAP2 protein (arrow).)

Related Product Information for anti-SKAP2 antibody

The protein encoded by this gene belongs to the src family kinases. This protein is similar to the src kinase associated phosphoprotein 1. It is an adaptor protein that is thought to play an essential role in the src signaling pathway in various cells. It inhibits PTK2B/RAFTK activity and regulates alpha-synuclein phosphorylation.

Product Categories/Family for anti-SKAP2 antibody

Antibodies; Protein Kinases

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). Qu, H.Q., et al. Hum. Mol. Genet. 19(12):2534-2538(2010). Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009). Barrett, J.C., et al. Nat. Genet. 41(6):703-707(2009). Voss, M., et al. BMC Immunol. 10, 53 (2009).

NCBI and Uniprot Product Information

• NCBI GI #: 16753212
• NCBI GeneID: 8935
• NCBI Accession #: NP_003921.2
• NCBI GenBank Nucleotide #: NM_003930.4
• UniProt Accession #: O75563; Q53GP6; Q75MK6; Q75MZ4; Q9UBZ3; Q9UED8; A4D173
• Molecular Weight: 41,217 Da
• NCBI Official Full Name: src kinase-associated phosphoprotein 2 isoform 1
• NCBI Official Synonym Full Names: src kinase associated phosphoprotein 2
• NCBI Official Symbol: SKAP2
• NCBI Official Synonym Symbols: PRAP; RA70; SAPS; SCAP2; SKAP55R; SKAP-HOM
• NCBI Protein Information: src kinase-associated phosphoprotein 2
• UniProt Protein Name: Src kinase-associated phosphoprotein 2
• Protein Family: Src kinase-associated phosphoprotein
• UniProt Gene Name: SKAP2
• UniProt Synonym Gene Names: PRAP; RA70; SAPS; SCAP2; SKAP55R; SKAP-55HOM; SKAP-HOM
• UniProt Entry Name: SKAP2_HUMAN

NCBI Description

The protein encoded by this gene shares homology with Src kinase-associated phosphoprotein 1, and is a substrate of Src family kinases. It is an adaptor protein that is thought to play an essential role in the Src signaling pathway, and in regulating proper activation of the immune system. This protein contains an amino terminal coiled-coil domain for self-dimerization, a plecskstrin homology (PH) domain required for interactions with lipids at the membrane, and a Src homology (SH3) domain at the carboxy terminus. Some reports indicate that this protein inhibits actin polymerization through interactions with actin assembly factors, and might negatively regulate the invasiveness of tumors by modulating actin assembly. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015]