Mouse anti-Human SK3 Polyclonal Antibody | anti-KCNN3 antibody

SK3, CT (SKCa3, KCNN3, K Ca 2.3, Small Conductance Ca2+-activated Potassium Channel 3, KCNN3, Potassium intermediate/small conductance calcium-activated channel subfamily N member 3)

Cat. Num. AAA6006273

• Gene Names: KCNN3; SK3; hSK3; SKCA3; KCa2.3
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Serum
• Synonyms: SK3; Polyclonal Antibody; CT (SKCa3; KCNN3; K Ca 2.3; Small Conductance Ca2+-activated Potassium Channel 3; Potassium intermediate/small conductance calcium-activated channel subfamily N member 3); Anti -SK3; anti-KCNN3 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human KCNN3.
• Purity/Purification: Serum
• Form/Format: Suppplied as a liquid in 50% glycerol.

• Applicable Applications for anti-KCNN3 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Optimal dilutions to be determined by the researcher.
• Immunogen: Partial recombinant protein corresponding to aa301-411 of human KCNN3 with a GST tag.
• Grade: Serum
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Western Blot (WB)

(Western Blot detection of KCNN3 expression in human retinoblastoma whole cell lysate using MBS6006273)

Related Product Information for anti-KCNN3 antibody

KCNN3 forms one of several calcium-activated potassium channels which are activated in a voltage-independent manner and have a relatively small unit conductance and high sensitivity to intracellular calcium. Activation is followed by membrane hyperpolarization. It is thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin. KCCN3 contains an intracellular N and C terminus and 6 highly conserved transmembrane segments. It exists as a heterooligomer composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding. These channels are thought to be potential therapeutic targets for disorders such as sleep apnea or sudden infant death syndrome and for regulating uterine contractions during labor. It was also suggested that KCNN3 may contribute to age-dependent decline in learning and memory and synaptic plasticity. Also it is thought that KCNN3 channel expression in endothelial cells may be a fundamental determinant of vascular tone and blood pressure.

Product Categories/Family for anti-KCNN3 antibody

Antibodies; Abs to Ion Channel

NCBI and Uniprot Product Information

• NCBI GI #: 323276683
• NCBI GeneID: 3782
• NCBI Accession #: NP_001191016.1
• NCBI GenBank Nucleotide #: NM_001204087.1
• UniProt Accession #: Q9UGI6; O43517; Q86VF9; Q8WXG7; B1ANX0
• NCBI Official Full Name: small conductance calcium-activated potassium channel protein 3 isoform c
• NCBI Official Synonym Full Names: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
• NCBI Official Symbol: KCNN3
• NCBI Official Synonym Symbols: SK3; hSK3; SKCA3; KCa2.3
• NCBI Protein Information: small conductance calcium-activated potassium channel protein 3; SKCa 3
• UniProt Protein Name: Small conductance calcium-activated potassium channel protein 3
• Protein Family: Small conductance calcium-activated potassium channel protein
• UniProt Gene Name: KCNN3
• UniProt Synonym Gene Names: K3; SK3; SKCa 3; SKCa3
• UniProt Entry Name: KCNN3_HUMAN

NCBI Description

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

Uniprot Description

KCNN3: Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin. Belongs to the potassium channel KCNN family. KCa2.3/KCNN3 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1q21.3

Cellular Component: cell soma; integral to membrane; plasma membrane

Molecular Function: calmodulin binding; small conductance calcium-activated potassium channel activity

Biological Process: synaptic transmission