Western Blot (WB)
(Western blot analysis of SIX1 expression in MCF-7 whole cell lysates (lane 1) and 22RV1 whole cell lysates (lane 2). SIX1 at 37KD was detected using rabbit anti- SIX1 Antigen Affinity purified polyclonal antibody at0.5 ug/mL. The blot was developed using chemiluminescence (ECL) method. )
anti-Human SIX1 Polyclonal Antibody | anti-SIX1 antibody
Anti-SIX1 Antibody
Western Blot (WB)
(Western blot analysis of SIX1 expression in MCF-7 whole cell lysates (lane 1) and 22RV1 whole cell lysates (lane 2). SIX1 at 37KD was detected using rabbit anti- SIX1 Antigen Affinity purified polyclonal antibody at0.5 ug/mL. The blot was developed using chemiluminescence (ECL) method. )
Western Blot (WB)
(Western blot analysis of SIX1 expression in MCF-7 whole cell lysates (lane 1) and 22RV1 whole cell lysates (lane 2). SIX1 at 37KD was detected using rabbit anti- SIX1 Antigen Affinity purified polyclonal antibody at0.5 ug/mL. The blot was developed using chemiluminescence (ECL) method. )
Background: Homeobox protein SIX1 (Sineoculis homeobox homolog 1) is a protein that in humans is encoded by the SIX1 gene. It is mapped to 14q23.1. The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb development. Defects in this gene are a cause of autosomal dominant deafness type 23 (DFNA23) and branchiootic syndrome type 3 (BOS3).
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb development. Defects in this gene are a cause of autosomal dominant deafness type 23 (DFNA23) and branchiootic syndrome type 3 (BOS3). [provided by RefSeq, Jul 2008]
Uniprot Description
SIX1: May be involved in limb tendon and ligament development. Defects in SIX1 are the cause of deafness autosomal dominant type 23 (DFNA23). A form of non-syndromic deafness characterized by prelingual, bilateral, symmetric hearing loss with a conductive component present in some but not all patients. Defects in SIX1 are the cause of branchiootic syndrome type 3 (BOS3). BOS3 is a syndrome characterized by usually bilateral branchial cleft fistulas or cysts, sensorineural and/or conductive hearing loss, pre-auricular pits, and structural defects of the outer, middle or inner ear. Otic defects include malformed and hypoplastic pinnae, a narrowed external ear canal, bulbous internal auditory canal, stapes fixation, malformed and hypoplastic cochlea. Branchial and otic anomalies are as those seen in individuals with the branchiootorenal syndrome. However, renal anomalies are absent in branchiootic syndrome patients. Defects in SIX1 could be a cause of branchiootorenal syndrome (BOR). BOR is an autosomal dominant disorder manifested by various combinations of preauricular pits, branchial fistulae or cysts, lacrimal duct stenosis, hearing loss, structural defects of the outer, middle, or inner ear, and renal dysplasia. Associated defects include asthenic habitus, long narrow facies, constricted palate, deep overbite, and myopia. Hearing loss may be due to mondini type cochlear defect and stapes fixation. Penetrance of BOR syndrome is high, although expressivity can be extremely variable. Belongs to the SIX/Sine oculis homeobox family.
Protein type: Transcription factor; Cell development/differentiation; DNA-binding
Chromosomal Location of Human Ortholog: 14q23.1
Cellular Component: cytoplasm; nucleolus; nucleus; transcription factor complex
Molecular Function: chromatin binding; DNA binding; protein binding; sequence-specific DNA binding; transcription factor activity
Biological Process: apoptosis; cell proliferation; embryonic cranial skeleton morphogenesis; embryonic skeletal morphogenesis; epithelial cell differentiation; facial nerve morphogenesis; generation of neurons; induction of an organ; inner ear development; inner ear morphogenesis; kidney development; middle ear morphogenesis; myoblast migration; negative regulation of neuron apoptosis; negative regulation of transcription from RNA polymerase II promoter; neuron fate specification; olfactory placode formation; pattern specification process; pharyngeal system development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of epithelial cell proliferation; regulation of neuron differentiation; regulation of protein localization; regulation of satellite cell proliferation; regulation of synaptic growth at neuromuscular junction; regulation of transcription, DNA-dependent; sensory perception of sound; skeletal muscle development; thymus development; thyroid gland development; transcription from RNA polymerase II promoter; ureteric bud branching; ureteric bud development
Disease: Branchiootic Syndrome 3; Branchiootorenal Syndrome 1; Deafness, Autosomal Dominant 23
Research Articles on SIX1
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Product Notes
The SIX1 six1 (Catalog #AAA177809) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-SIX1 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SIX1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot Concentration: 0.1-0.5ug/ml. Researchers should empirically determine the suitability of the SIX1 six1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SIX1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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