Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human heart tissue slide using MBS7604113 (SIRT2 Antibody) at dilution of 1:50)
Rabbit SIRT2 Polyclonal Antibody | anti-SIRT2 antibody
SIRT2-Specific Rabbit Polyclonal
Immunogen Affinity Purified
Immunogen Affinity Purified
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human heart tissue slide using MBS7604113 (SIRT2 Antibody) at dilution of 1:50)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human heart tissue slide using MBS7604113 (SIRT2 Antibody) at dilution of 1:50)
Western Blot (WB)
(rat brain tissue were subjected to SDS PAGE followed by western blot with MBS7604113 (SIRT2 antibody) at dilution of 1:600)
Western Blot (WB)
(rat brain tissue were subjected to SDS PAGE followed by western blot with MBS7604113 (SIRT2 antibody) at dilution of 1:600)
NCBI and Uniprot Product Information
Uniprot Description
SIRT2: NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and non-histone proteins. Deacetylates 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Deacetylates PCK1, opposing proteasomal degradation. Deacetylates 'Lys-310' of RELA. Interacts with HDAC6, suggesting that these proteins belong to a large complex that deacetylate the cytoskeleton. Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulation of microtubule network. Inhibited by Sirtinol, A3 and M15 small molecules. Inhibited by nicotinamide. Belongs to the sirtuin family. Class I subfamily. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Deacetylase; EC 3.5.1.-
Chromosomal Location of Human Ortholog: 19q13
Cellular Component: centriole; centrosome; chromosome; cytoplasm; cytosol; lateral loop; microtubule; midbody; myelin sheath; nuclear heterochromatin; nucleus; paranode region of axon; perikaryon; perinuclear region of cytoplasm; spindle
Molecular Function: chromatin binding; histone acetyltransferase binding; histone deacetylase activity; histone deacetylase binding; NAD+ ADP-ribosyltransferase activity; NAD-dependent histone deacetylase activity; NAD-dependent histone deacetylase activity (H4-K16 specific); protein binding; protein deacetylase activity; transcription factor binding; tubulin deacetylase activity; ubiquitin binding; zinc ion binding
Biological Process: cellular lipid catabolic process; hepatocyte growth factor receptor signaling pathway; histone deacetylation; myelination in the peripheral nervous system; negative regulation of autophagy; negative regulation of cell proliferation; negative regulation of fat cell differentiation; negative regulation of protein catabolic process; negative regulation of striated muscle development; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; phosphoinositide 3-kinase cascade; positive regulation of attachment of spindle microtubules to kinetochore; positive regulation of cell division; positive regulation of DNA binding; positive regulation of meiosis; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of transcription from RNA polymerase II promoter; proteasomal ubiquitin-dependent protein catabolic process; protein amino acid ADP-ribosylation; protein amino acid deacetylation; protein kinase B signaling cascade; regulation of cell cycle; regulation of myelination; substantia nigra development
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Product Notes
The SIRT2 sirt2 (Catalog #AAA7604113) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SIRT2-Specific Rabbit Polyclonal reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's SIRT2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB), Immunofluorescence (IF), Immunoprecipitation (IP). Researchers should empirically determine the suitability of the SIRT2 sirt2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SIRT2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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