Rabbit anti-Human SIRPB1 Polyclonal Antibody | anti-SIRPB1 antibody

SIRPB1, ID (SIRPB1, Signal-regulatory protein beta-1, CD172 antigen-like family member B, CD172b) (PE)

Cat. Num. AAA6347757

• Gene Names: SIRPB1; CD172b; SIRP-BETA-1
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: SIRPB1; Polyclonal Antibody; ID (SIRPB1; Signal-regulatory protein beta-1; CD172 antigen-like family member B; CD172b) (PE); CD172b; anti-SIRPB1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-SIRPB1 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: SIRPB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 107-134 amino acids from the Central region of human SIRPB1.
• Conjugate: PE
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(SIRPB1 Antibody (Center) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the SIRPB1 antibody detected the SIRPB1 protein (arrow).)

Related Product Information for anti-SIRPB1 antibody

The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

Product Categories/Family for anti-SIRPB1 antibody

Antibodies; CD Markers

References

Gaikwad, S., et al. Am. J. Pathol. 175(6):2528-2539(2009). Martins-de-Souza, D., et al. Eur Arch Psychiatry Clin Neurosci 259(3):151-163(2009). Martins-de-Souza, D., et al. J Neural Transm 116(3):275-289(2009). Lamesch, P., et al. Genomics 89(3):307-315(2007). van den Berg, T.K., et al. J. Immunol. 175(12):7788-7789(2005).

NCBI and Uniprot Product Information

• NCBI GI #: 144953878
• NCBI GeneID: 10326
• NCBI Accession #: NP_001077379.1
• NCBI GenBank Nucleotide #: NM_001083910.2
• UniProt Accession #: O00241; Q5TFQ9; Q5TFR0; Q8TB12; Q9H1U5; Q9Y4V0; A6NLM2; B2R8V0; Q5TFQ8
• Molecular Weight: 43,211 Da
• NCBI Official Full Name: signal-regulatory protein beta-1 isoform 2
• NCBI Official Synonym Full Names: signal-regulatory protein beta 1
• NCBI Official Symbol: SIRPB1
• NCBI Official Synonym Symbols: CD172b; SIRP-BETA-1
• NCBI Protein Information: signal-regulatory protein beta-1; CD172 antigen-like family member B
• UniProt Protein Name: Signal-regulatory protein beta-1
• Protein Family: Signal-regulatory protein
• UniProt Gene Name: SIRPB1
• UniProt Synonym Gene Names: SIRP-beta-1
• UniProt Entry Name: SIRB1_HUMAN

NCBI Description

The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

Uniprot Description

SIRPB1: Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 20p13

Cellular Component: integral to plasma membrane; integral to membrane; plasma membrane

Molecular Function: protein binding

Biological Process: cell surface receptor linked signal transduction; innate immune response; signal transduction