Rabbit SIPA1L1 Polyclonal Antibody | anti-SIPA1L1 antibody
SIPA1L1 Antibody
Gene Names
SIPA1L1; E6TP1
Reactivity
Human, Mouse, Rat
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
SIPA1L1; Polyclonal Antibody; SIPA1L1 Antibody; DKFZp686G1344; E6 targeted protein 1; E6TP1; H_DJ1140G11.1; High risk human papilloma viruses E6 oncoproteins targeted protein 1; KIAA0440; Signal induced proliferation associated 1 like 1; Signal induced proliferation associated 1 like protein 1; SIPA1 like protein 1; WUGSC:H_DJ1140G11.1; anti-SIPA1L1 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
SIPA1L1 Antibody detects endogenous levels of SIPA1L1.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-SIPA1L1 antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from human SIPA1L1.
Conjugation
Unconjugated
Post Translational Modifications
Ubiquitinated and degraded by the SCF(BTRC) following phosphorylation by PLK2.Phosphorylated at Ser-1349 by CDK5, creating a docking site for the POLO box domains of PLK2. Subsequently, PLK2 binds and phosphorylates SIPA1L1, leading to ubiquitination and degradation by the proteasome (By similarity).
Subunit Structure
Interacts with DLG4, PDLIM5, PDLIM7 and LZTS3. Interacts with the actin cytoskeleton (By similarity). Interacts (via PDZ domain) with EPHA4 (via PDZ motif); controls neuronal morphology through regulation of the RAP1 (RAP1A or RAP1B) and RAP2 (RAP2A, RAP2B or RAP2C) GTPases. Interacts with HPV E6.
Tissue Specificity
Widely expressed.
Function
Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity).
Note
Associated with the actin cytoskeleton. Detected at synapses and dendritic spines of cultured hippocampal neurons (By similarity).
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Product Categories/Family for anti-SIPA1L1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
197,408 Da
NCBI Official Full Name
signal-induced proliferation-associated 1-like protein 1 isoform 1
NCBI Official Synonym Full Names
signal-induced proliferation-associated 1 like 1
NCBI Official Symbol
SIPA1L1
NCBI Official Synonym Symbols
E6TP1
NCBI Protein Information
signal-induced proliferation-associated 1-like protein 1; SIPA1-like protein 1; high-risk human papilloma viruses E6 oncoproteins targeted protein 1
UniProt Protein Name
Signal-induced proliferation-associated 1-like protein 1
Protein Family
UniProt Gene Name
SIPA1L1
UniProt Synonym Gene Names
E6TP1; KIAA0440; SIPA1-like protein 1; E6-targeted protein 1
UniProt Entry Name
SI1L1_HUMAN
Uniprot Description
SIPA1L1: Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F- actin. Contributes to the regulation of dendritic spine morphogenesis. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: GAPs, Ras; GAPs
Chromosomal Location of Human Ortholog: 14q24.2
Cellular Component: postsynaptic membrane; cytoskeleton; cytoplasm; postsynaptic density; dendritic spine; cell junction
Molecular Function: ephrin receptor binding; GTPase activator activity
Biological Process: actin cytoskeleton reorganization; ephrin receptor signaling pathway; regulation of synaptic plasticity; regulation of axonogenesis
Research Articles on SIPA1L1
Similar Products
Product Notes
The SIPA1L1 sipa1l1 (Catalog #AAA9631309) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SIPA1L1 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's SIPA1L1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the SIPA1L1 sipa1l1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SIPA1L1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
