Rabbit anti-Human SIPA1 Polyclonal Antibody | anti-SIPA1 antibody

SIPA1 Antibody

Cat. Num. AAA9412920

• Gene Names: SIPA1; SPA1
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity chromatography purified via peptide column
• Synonyms: SIPA1; Polyclonal Antibody; SIPA1 Antibody; Signal-induced proliferation associated-1; SPA1; anti-SIPA1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: At least three isoforms of SIPA1 are known to exist; this antibody will recognize all three isoforms. This antibody is specific for SIPA1 and will not recognize the other SIPA1 family of proteins.
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 1042

• Applicable Applications for anti-SIPA1 antibody: ELISA (EIA), Western Blot (WB)
• Immunogen Type: Peptide
• Immunogen Description: Raised against a 19 amino acid peptide from near the amino terminus of human SIPA1.
• Target Name: SIPA1
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of SIPA1 in human brain tissue lysate with SIPA1 antibody at 1 ug/mL.)

Related Product Information for anti-SIPA1 antibody

Signal-induced proliferation 1 (SIPA1) is a member of the SIPA1 family of RapGAPs, a family of mitogen-induced GTPase activating proteins. SIPA1 exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. When abnormally or prematurely expressed, SIPA1 may also hamper mitogen-induced cell cycle progression and may increase metastases in human cancers.

Product Categories/Family for anti-SIPA1 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 14714701
• NCBI GeneID: 6494
• Molecular Weight: 112,149 Da
• NCBI Official Full Name: Signal-induced proliferation-associated 1
• NCBI Official Synonym Full Names: signal-induced proliferation-associated 1
• NCBI Official Symbol: SIPA1
• NCBI Official Synonym Symbols: SPA1
• NCBI Protein Information: signal-induced proliferation-associated protein 1
• UniProt Protein Name: Signal-induced proliferation-associated protein 1
• Protein Family: Signal-induced proliferation-associated protein
• UniProt Gene Name: SIPA1
• UniProt Synonym Gene Names: SPA1; Sipa-1
• UniProt Entry Name: SIPA1_HUMAN

NCBI Description

The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date. [provided by RefSeq, Jul 2008]

Uniprot Description

SIPA1: GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting it to the putatively inactive GDP-bound state.

Protein type: GAPs, Ras; GAPs

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: Golgi apparatus; transport vesicle; protein complex; perinuclear region of cytoplasm; plasma membrane; nucleolus; nucleus; cytosol

Molecular Function: protein C-terminus binding; protein binding; GTPase activator activity

Biological Process: cell proliferation; cytoskeleton organization and biogenesis; cellular response to water deprivation; negative regulation of cell growth; negative regulation of cell adhesion; signal transduction; positive regulation of GTPase activity; negative regulation of cell cycle