Rabbit SIP1 Polyclonal Antibody | anti-SIP1 antibody

SIP1 Antibody FITC Conjugated

Cat. Num. AAA9461941

• Gene Names: ZEB2; SIP1; SIP-1; ZFHX1B; HSPC082; SMADIP1
• Reactivity: Human, Mouse, Rat
• Applications: Immunofluorescence
• Purity: Purified by Protein A
• Synonyms: SIP1; Polyclonal Antibody; SIP1 Antibody FITC Conjugated; Smad Interacting Protein 1 SIP 1; SIP1 SIP-1; Smad-interacting protein 1; SMADIP 1; SMADIP1; ZEB 2; ZEB2; ZEB2_HUMAN; Zfhx1b; ZFHX1B protein; Zfx1b; Zinc finger E box binding protein 2; Zinc finger E-box-binding homeobox 2; Zinc finger homeobox 1b; zinc finger homeobox protein 1; Zinc finger homeobo; anti-SIP1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A
• Form/Format: 10mM Tris Buffered Saline containing 1% BSA, 50% glycerol and 0.09% sodium azide.
• Concentration: 1mgml (varies by lot)

• Applicable Applications for anti-SIP1 antibody: Immunofluorescence (IF)
• Application Notes: IF: 1:50-200
• Conjugation: FITC
• Excitation Emission: 494nm 518nm
• Immunogen: KLH conjugated synthetic peptide derived from human SIP1
• Preparation and Storage: Store at 4 degree C for 12 months.

Related Product Information for anti-SIP1 antibody

SMAD regulates gene expression by interacting with different classes of transcription factors including DNA-binding multi-zinc finger proteins. SIP1, for SMAD interacting protein 1, is a member of the delta-EF1 Zfh1 family of 2-handed zinc finger homeodomain proteins. SIP1 contains a SMAD-binding domain, a homeodomain and two clusters of zinc fingers on the N- and C-termini. SIP1, also known as SMADIP1, ZFHX1B and ZEB2 (zinc finger E-box-binding protein 2), can be induced by TGFbeta treatment. SIP1 plays a crucial role in normal embryonic development of neural structures and the neural crest. The human SIP1 gene maps to chromosome 2q22. Mutations in the SIP1 gene cause a form of Hirschsprung disease (HSCR). Patients with SIP1 mutations show mental retardation, delayed motor development, epilepsy, microcephaly, distinct facial features and or congenital heart diseaseaall symptoms of HSCR.

Product Categories/Family for anti-SIP1 antibody

Conjugated Primary Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 284413746
• NCBI GeneID: 9839
• NCBI Accession #: NP_001165124.1
• NCBI GenBank Nucleotide #: NM_001171653.1
• UniProt Accession #: O60315; Q9UED1; A0JP09; B7Z2P2; F5H814
• Molecular Weight: 136,447 Da
• NCBI Official Full Name: zinc finger E-box-binding homeobox 2 isoform 2
• NCBI Official Synonym Full Names: zinc finger E-box binding homeobox 2
• NCBI Official Symbol: ZEB2
• NCBI Official Synonym Symbols: SIP1; SIP-1; ZFHX1B; HSPC082; SMADIP1
• NCBI Protein Information: zinc finger E-box-binding homeobox 2; zinc finger homeobox 1b; SMAD interacting protein 1; Smad-interacting protein 1
• UniProt Protein Name: Zinc finger E-box-binding homeobox 2
• Protein Family: SNF1 protein kinase
• UniProt Gene Name: ZEB2
• UniProt Synonym Gene Names: KIAA0569; SIP1; ZFHX1B; ZFX1B; SMADIP1
• UniProt Entry Name: ZEB2_HUMAN

NCBI Description

The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jan 2010]

Uniprot Description

ZEB2: Transcriptional inhibitor that binds to DNA sequence 5'- CACCT-3' in different promoters. Represses transcription of E- cadherin. Defects in ZEB2 are the cause of Mowat-Wilson syndrome (MWIS); also known as Hirschsprung disease-mental retardation syndrome. A complex developmental disorder characterized by mental retardation, delayed motor development, epilepsy, microcephaly and a wide spectrum of clinically heterogeneous features suggestive of neurocristopathies at the cephalic, cardiac, and vagal levels. Some patients manifest Hirschsprung disease. Affected patients show an easily recognizable facial appearance with deep set eyes and hypertelorism, medially divergent, broad eyebrows, prominent columella, pointed chin and uplifted, notched ear lobes. Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.

Protein type: Motility/polarity/chemotaxis; Transcription, coactivator/corepressor; DNA-binding; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 2q22.3

Cellular Component: nucleus

Molecular Function: DNA binding; phosphatase regulator activity; metal ion binding

Biological Process: positive regulation of JNK activity; nervous system development; somitogenesis; transcription, DNA-dependent; cell proliferation in forebrain; pigmentation during development; hippocampus development; positive regulation of melanin biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; positive regulation of melanocyte differentiation; neural tube closure; positive regulation of transcription from RNA polymerase II promoter; neural crest cell migration; positive regulation of Wnt receptor signaling pathway

Disease: Mowat-wilson Syndrome