Western Blot (WB)
(Mouse Sin3a Antibody (C-term) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the Sin3a antibody detected the Sin3a protein (arrow).)
Rabbit anti-Mouse Sin3a Polyclonal Antibody | anti-Sin3a antibody
Sin3a, CT (Sin3a, Kiaa4126, Paired amphipathic helix protein Sin3a, Histone deacetylase complex subunit Sin3a, Transcriptional corepressor Sin3a) (AP)
ELISA: 1:1,000
Applications are based on unconjugated antibody.
Western Blot (WB)
(Mouse Sin3a Antibody (C-term) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the Sin3a antibody detected the Sin3a protein (arrow).)
Western Blot (WB)
(Mouse Sin3a Antibody (C-term) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the Sin3a antibody detected the Sin3a protein (arrow).)
NCBI and Uniprot Product Information
Uniprot Description
Function: Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Ref.2 Ref.5 Ref.12
Subunit structure: Interacts with ARID4B, BRMS1L, HCFC1, HDAC1, HDAC2, MXI1, SAP30L, SAP130, SFPQ and TOPORS. Interacts with OGT (via TPRs 1-6); the interaction mediates transcriptional repression in parallel with histone deacetylase
By similarity. Interacts with BAZ2A, MXD3, MXD4, MBD2, DACH1, NCOR1, NR4A2, REST, RLIM, SAP30, SETDB1, SMYD2, and SUDS3. Interacts with PHF12 in a complex composed of HDAC1, PHF12 and SAP30. Interacts with TET1; the interaction recruits SIN3A to gene promoters. Ref.2 Ref.5 Ref.7 Ref.9 Ref.10 Ref.11 Ref.12 Ref.13 Ref.14 Ref.15 Ref.16 Ref.17 Ref.18 Ref.19 Ref.21 Ref.23
Subcellular location: Nucleus. Nucleus › nucleolus. Note: Recruited to the nucleolus by SAP30L
By similarity.
Tissue specificity: Widely expressed. Highest levels in testis, lung and thymus.
Post-translational modification: SUMO1 sumoylated by TOPORS. Probably desumoylated by SENP2
By similarity.
Sequence similarities: Contains 3 PAH (paired amphipathic helix) domains.
Sequence caution: The sequence AAB01610.1 differs from that shown. Reason: The cDNA contains an internal 15bp tandem duplication.The sequence AAH52716.1 differs from that shown. Reason: Probable cloning artifact leading to an internal deletion.The sequence AAH53385.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.The sequence BAD90217.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
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Product Notes
The Sin3a sin3a (Catalog #AAA6347725) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Sin3a, CT (Sin3a, Kiaa4126, Paired amphipathic helix protein Sin3a, Histone deacetylase complex subunit Sin3a, Transcriptional corepressor Sin3a) (AP) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Sin3a can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB: 1:100-500 ELISA: 1:1,000 Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the Sin3a sin3a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Sin3a, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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