Rabbit anti-Human Signal Transducer And Activator Of Transcription 6 (STAT6) Polyclonal Antibody | anti-STAT6 antibody

Polyclonal Antibody to Signal Transducer And Activator Of Transcription 6 (STAT6)

Cat. Num. AAA2003220

• Reactivity: Human
• Applications: Immunocytochemistry, Immunohistochemistry, ELISA, Western Blot
• Purity: Affinity Chromatography
• Synonyms: Signal Transducer And Activator Of Transcription 6 (STAT6); Polyclonal Antibody; Polyclonal Antibody to Signal Transducer And Activator Of Transcription 6 (STAT6); anti-STAT6 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody is a rabbit polyclonal antibody raised against STAT6. It has been selected for its ability to recognize STAT6 in immunohistochemical staining andwestern blotting.
• Purity/Purification: Affinity Chromatography
• Form/Format: Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
• Concentration: 500ug/mL (varies by lot)
• Sequence: Antigen: The target protein is fused with two N-terminal Tags, His-tag and its sequence is listed below.; MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF-DEVLRTLVT SCFLVEKQPP QVLKTQTKFQ AGVRFLLGLR FLGAPAKPPL VRADMVTEKQ ARELSVPQGP GAGAESTGEI INNTVPLENS IPGNCCSALF KNLLLKKIKR CERKGTESVT EEKCAVLFSA SFTLGPGKLP IQLQALSLPL VVIVHGNQDN NAKATILWDN AFSEMDRVPF VVAERVPWEK MCETLNLKFM AEVGTNRGLL PEHFLFLAQK IFNDNSLSME AFQHRSVSWS QFNKEILLGR GFTFWQWFDG
• Sequence Length: 847

• Applicable Applications for anti-STAT6 antibody: Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
• Application Notes: Western blotting: 1:100-400; Immunocytochemistry in formalin fixed cells: 1:100-500; Immunohistochemistry in formalin fixed frozen section: 1:100-500; Immunohistochemistry in paraffin section: 1:50-200; Enzyme-linked Immunosorbent Assay: 1:100-200
• Immunogen: Recombinant STAT6 (Asp262~Gly520) expressed in E.coli.
• Cross Reactivity: Human
• Conjugated Antibody: The APC conjugated antibody version of this item is also available as catalog #MBS2058458
• Preparation and Storage: Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Western Blot (WB)

(Western Blot: Sample: Recombinant STAT6, Human.)

Immunohistochemistry (IHC)

(DABstainingonIHC-P.Samples:HumanTissue))

NCBI and Uniprot Product Information

• NCBI GI #: 113205500
• NCBI GeneID: 362896
• NCBI Accession #: NP_001037715.1
• NCBI GenBank Nucleotide #: NM_001044250.1
• UniProt Accession #: Q1KQ07
• Molecular Weight: 93,870 Da
• NCBI Official Full Name: signal transducer and activator of transcription 6
• NCBI Official Synonym Full Names: signal transducer and activator of transcription 6
• NCBI Official Symbol: Stat6
• NCBI Protein Information: signal transducer and activator of transcription 6
• UniProt Protein Name: Signal transducer and activator of transcription
• Protein Family: Signal transducer and transcription activator
• UniProt Gene Name: Stat6

Uniprot Description

STAT6: transcription factor of the STAT family. Plays a central role in IL4-mediated biological responses. Induces the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. May function in the differentiation of T helper 2 cells and class switch of immunoglobulins. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 7q22

Cellular Component: cytoplasm; cytosol; membrane raft; nuclear chromatin; nuclear membrane; nucleoplasm; nucleus

Molecular Function: DNA binding; DNA binding transcription factor activity; identical protein binding; protein phosphatase binding; sequence-specific DNA binding; signal transducer activity

Biological Process: cellular response to hydrogen peroxide; cellular response to reactive nitrogen species; cytokine-mediated signaling pathway; mammary gland epithelial cell proliferation; negative regulation of T-helper 2 type immune response; negative regulation of transcription from RNA polymerase II promoter; positive regulation of isotype switching to IgE isotypes; positive regulation of transcription from RNA polymerase II promoter; regulation of cell proliferation; response to cytokine; signal transduction; T-helper 1 cell lineage commitment; transcription from RNA polymerase II promoter