Mouse anti-Human SHOX Polyclonal Antibody | anti-SHOX antibody

SHOX (Short Stature Homeobox Protein, Pseudoautosomal Homeobox-containing Osteogenic Protein, Short Stature Homeobox-containing Protein, PHOG)

Cat. Num. AAA649636

• Gene Names: SHOX; SS; GCFX; PHOG; SHOXY
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: SHOX; Polyclonal Antibody; SHOX (Short Stature Homeobox Protein; Pseudoautosomal Homeobox-containing Osteogenic Protein; Short Stature Homeobox-containing Protein; PHOG); Anti -SHOX (Short Stature Homeobox Protein; anti-SHOX antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human SHOX.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.
• Sequence: MEELTAFVSKSFDQKSKDGNGGGGGGGGKKDSITYREVLESGLARSRELGTSDSSLQDITEGGGHCPVHLFKDHVDNDKEKLKEFGTARVAEGIYECKEKREDVKSEDEDGQTKLKQRRSRTNFTLEQLNELERLFDETHYPDAFMREELSQRLGLSEARVQVWFQNRRAKCRKQENQMHKGVILGTANHLDACRVAPYVNMGALRMPFQQMEFCSCRPGWSIMA

• Applicable Applications for anti-SHOX antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.
• Immunogen: Full length human SHOX, aa1-225 (NP_006874.1).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(SHOX polyclonal antibody. Western Blot analysis of SHOX expression in human liver.)

Western Blot (WB)

(Western Blot analysis of SHOX expression in transfected 293T cell line by SHOX polyclonal antibody. Lane 1: SHOX transfected lysate (24.75kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-SHOX antibody

This gene belongs to the paired homeobox family and is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. Defects in this gene are associated with idiopathic growth retardation and in the short stature phenotype of Turner syndrome patients. This gene is highly conserved across species from mammals to fish to flies. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Product Categories/Family for anti-SHOX antibody

Antibodies; Abs to Transcription Factors; Homeobox (HOX)

NCBI and Uniprot Product Information

• NCBI GI #: 6031203
• NCBI GeneID: 6473
• NCBI Accession #: NP_006874.1
• NCBI GenBank Nucleotide #: NM_006883.2
• UniProt Accession #: O15266; O00412; O00413; O15267
• Molecular Weight: 32,236 Da
• NCBI Official Full Name: short stature homeobox protein isoform SHOXb
• NCBI Official Synonym Full Names: short stature homeobox
• NCBI Official Symbol: SHOX
• NCBI Official Synonym Symbols: SS; GCFX; PHOG; SHOXY
• NCBI Protein Information: short stature homeobox protein; growth control factor, X-linked; pseudoautosomal homeobox-containing osteogenic protein
• UniProt Protein Name: Short stature homeobox protein
• Protein Family: Short stature homeobox protein
• UniProt Gene Name: SHOX
• UniProt Synonym Gene Names: PHOG
• UniProt Entry Name: SHOX_HUMAN

NCBI Description

This gene belongs to the paired homeobox family and is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. Defects in this gene are associated with idiopathic growth retardation and in the short stature phenotype of Turner syndrome patients. This gene is highly conserved across species from mammals to fish to flies. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Controls fundamental aspects of growth and development.

Subcellular location: Nucleus

By similarity.

Tissue specificity: SHOXA is expressed in skeletal muscle, placenta, pancreas, heart and bone marrow fibroblast and SHOXB is highly expressed in bone marrow fibroblast followed by kidney and skeletal muscle. SHOXB is not expressed in brain, kidney, liver and lung. Highly expressed in osteogenic cells.

Induction: By retinoic acid and phorbol-12-myristate 13-acetate (PMA).

Involvement in disease: Leri-Weill dyschondrosteosis (LWD) [MIM:127300]: Dominantly inherited skeletal dysplasia characterized by moderate short stature predominantly because of short mesomelic limb segments. It is often associated with the Madelung deformity of the wrist, comprising bowing of the radius and dorsal dislocation of the distal ulna.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.4 Ref.5 Ref.6Langer mesomelic dysplasia (LMD) [MIM:249700]: Autosomal recessive rare skeletal dysplasia characterized by severe short stature owing to shortening and maldevelopment of the mesomelic and rhizomelic segments of the limbs. Associated malformations are rarely reported and intellect is normal in all affected subjects reported to date.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.5 Ref.7Short stature, idiopathic, X-linked (ISS) [MIM:300582]: A condition defined by a standing height more than 2 standard deviations below the mean (or below the 2.5 percentile) for sex and chronological age, compared with a well-nourished, genetically relevant population, in the absence of specific causative disorders.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.1 Ref.5

Miscellaneous: The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

Sequence similarities: Belongs to the paired homeobox family. Bicoid subfamily.Contains 1 homeobox DNA-binding domain.