Rabbit anti-Human SHOX Polyclonal Antibody | anti-SHOX antibody

SHOX, CT (Short stature homeobox protein,SHOX,PHOG) (APC)

Cat. Num. AAA6347473

• Gene Names: SHOX; SS; GCFX; PHOG; SHOXY
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: SHOX; Polyclonal Antibody; CT (Short stature homeobox protein; PHOG) (APC); Short stature homeobox protein; PHOG; anti-SHOX antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-SHOX antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: SHOX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 262-290 amino acids from the C-terminal region of human SHOX.
• Conjugate: APC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Testing Data

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Related Product Information for anti-SHOX antibody

This gene belongs to the paired homeobox family and is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. Defects in this gene are associated with idiopathic growth retardation and in the short stature phenotype of Turner syndrome patients. This gene is highly conserved across species from mammals to fish to flies. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Product Categories/Family for anti-SHOX antibody

Antibodies; Transcription Factors; Zinc; Ring; Homeobox

References

Barroso, E., et al. Eur J Med Genet 53(4):204-207(2010). D'haene, B., et al. J. Clin. Endocrinol. Metab. 95(6):3010-3018(2010). Durand, C., et al. Eur. J. Hum. Genet. 18(5):527-532(2010). Chen, J., et al. J. Med. Genet. 46(12):834-839(2009). Gahunia, H.K., et al. Semin Musculoskelet Radiol 13(3):236-254(2009).

NCBI and Uniprot Product Information

• NCBI GI #: 4506943
• NCBI GeneID: 6473
• NCBI Accession #: NP_000442.1; NP_006874.1
• NCBI GenBank Nucleotide #: NM_000451.3
• UniProt Accession #: O15266; O00412; O00413; O15267
• Molecular Weight: 25,501 Da
• NCBI Official Full Name: short stature homeobox protein isoform SHOXa
• NCBI Official Synonym Full Names: short stature homeobox
• NCBI Official Symbol: SHOX
• NCBI Official Synonym Symbols: SS; GCFX; PHOG; SHOXY
• NCBI Protein Information: short stature homeobox protein; growth control factor, X-linked; pseudoautosomal homeobox-containing osteogenic protein
• UniProt Protein Name: Short stature homeobox protein
• Protein Family: Short stature homeobox protein
• UniProt Gene Name: SHOX
• UniProt Synonym Gene Names: PHOG
• UniProt Entry Name: SHOX_HUMAN

NCBI Description

This gene belongs to the paired homeobox family and is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. Defects in this gene are associated with idiopathic growth retardation and in the short stature phenotype of Turner syndrome patients. This gene is highly conserved across species from mammals to fish to flies. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Controls fundamental aspects of growth and development.

Subcellular location: Nucleus

By similarity.

Tissue specificity: SHOXA is expressed in skeletal muscle, placenta, pancreas, heart and bone marrow fibroblast and SHOXB is highly expressed in bone marrow fibroblast followed by kidney and skeletal muscle. SHOXB is not expressed in brain, kidney, liver and lung. Highly expressed in osteogenic cells.

Induction: By retinoic acid and phorbol-12-myristate 13-acetate (PMA).

Involvement in disease: Leri-Weill dyschondrosteosis (LWD) [MIM:127300]: Dominantly inherited skeletal dysplasia characterized by moderate short stature predominantly because of short mesomelic limb segments. It is often associated with the Madelung deformity of the wrist, comprising bowing of the radius and dorsal dislocation of the distal ulna.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.4 Ref.5 Ref.6Langer mesomelic dysplasia (LMD) [MIM:249700]: Autosomal recessive rare skeletal dysplasia characterized by severe short stature owing to shortening and maldevelopment of the mesomelic and rhizomelic segments of the limbs. Associated malformations are rarely reported and intellect is normal in all affected subjects reported to date.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.5 Ref.7Short stature, idiopathic, X-linked (ISS) [MIM:300582]: A condition defined by a standing height more than 2 standard deviations below the mean (or below the 2.5 percentile) for sex and chronological age, compared with a well-nourished, genetically relevant population, in the absence of specific causative disorders.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.1 Ref.5

Miscellaneous: The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

Sequence similarities: Belongs to the paired homeobox family. Bicoid subfamily.Contains 1 homeobox DNA-binding domain.