Rabbit anti-Human SFRS3 Polyclonal Antibody | anti-SFRS3 antibody

SFRS3, ID (SRSF3, SFRS3, SRP20, Serine/arginine-rich splicing factor 3, Pre-mRNA-splicing factor SRP20, Splicing factor, arginine/serine-rich 3) (AP)

Cat. Num. AAA6346691

• Gene Names: SRSF3; SFRS3; SRp20
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: SFRS3; Polyclonal Antibody; ID (SRSF3; SRP20; Serine/arginine-rich splicing factor 3; Pre-mRNA-splicing factor SRP20; Splicing factor; arginine/serine-rich 3) (AP); SRSF3; arginine/serine-rich 3; anti-SFRS3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).

• Applicable Applications for anti-SFRS3 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: SFRS3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-110 amino acids from the Central region of human SFRS3.
• Conjugate: AP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(SFRS3 Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the SFRS3 antibody detected the SFRS3 protein (arrow).)

Related Product Information for anti-SFRS3 antibody

SFRS3 is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants, one protein-coding and the other non-coding, have been found for this gene.

Product Categories/Family for anti-SFRS3 antibody

Antibodies; Splicing Factors

References

Verma, D., et al. J. Virol. 84(22):11781-11789(2010). Anko, M.L., et al. Nat. Struct. Mol. Biol. 17(8):962-970(2010). Escudero-Paunetto, L., et al. Virology 401(2):155-164(2010). Manley, J.L., et al. Genes Dev. 24(11):1073-1074(2010). Fingert, J.H., et al. Mol. Vis. 16, 596-601 (2010).

NCBI and Uniprot Product Information

• NCBI GI #: 4506901
• NCBI GeneID: 6428
• NCBI Accession #: NP_003008.1
• NCBI GenBank Nucleotide #: NM_003017.4
• UniProt Accession #: P84103; O08831; P23152; Q5R3K0
• Molecular Weight: 19,330 Da
• NCBI Official Full Name: serine/arginine-rich splicing factor 3
• NCBI Official Synonym Full Names: serine/arginine-rich splicing factor 3
• NCBI Official Symbol: SRSF3
• NCBI Official Synonym Symbols: SFRS3; SRp20
• NCBI Protein Information: serine/arginine-rich splicing factor 3; pre-mRNA-splicing factor SRP20; splicing factor, arginine/serine-rich 3; splicing factor, arginine/serine-rich, 20-kD
• UniProt Protein Name: Serine/arginine-rich splicing factor 3
• UniProt Gene Name: SRSF3
• UniProt Synonym Gene Names: SFRS3; SRP20
• UniProt Entry Name: SRSF3_HUMAN

NCBI Description

The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants, one protein-coding and the other non-coding, have been found for this gene. [provided by RefSeq, Sep 2010]

Uniprot Description

SFRS3: May be involved in RNA processing in relation with cellular proliferation and/or maturation. Belongs to the splicing factor SR family.

Protein type: Spliceosome; RNA-binding; RNA processing; RNA splicing

Chromosomal Location of Human Ortholog: 6p21

Cellular Component: nucleoplasm; cytoplasm

Molecular Function: protein binding; RNA binding; nucleotide binding

Biological Process: nuclear mRNA splicing, via spliceosome; transcription from RNA polymerase II promoter; mRNA export from nucleus; RNA splicing; gene expression; mRNA 3'-end processing; termination of RNA polymerase II transcription