Rabbit anti-Human SERPINA6 Polyclonal Antibody | anti-SERPINA6 antibody

SERPINA6 Rabbit Polyclonal

Cat. Num. AAA7603975

• Gene Names: SERPINA6; CBG
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry, Western Blot
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: SERPINA6; Polyclonal Antibody; SERPINA6 Rabbit Polyclonal; anti-SERPINA6 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 405

• Applicable Applications for anti-SERPINA6 antibody: ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)
• Immunogen: Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human kidney tissue slide using MBS7603975 (Corticosteroid binding globulin Antibody) at dilution of 1:200)

Western Blot (WB)

(human plasma tissue were subjected to SDS PAGE followed by western blot with MBS7603975 (Corticosteroid binding globulin Antibody) at dilution of 1:600)

NCBI and Uniprot Product Information

• NCBI GI #: 823672932
• NCBI GeneID: 866
• Molecular Weight: 45,141 Da
• NCBI Official Full Name: SERPINA6, partial
• NCBI Official Synonym Full Names: serpin family A member 6
• NCBI Official Symbol: SERPINA6
• NCBI Official Synonym Symbols: CBG
• NCBI Protein Information: corticosteroid-binding globulin
• UniProt Protein Name: Corticosteroid-binding globulin
• Protein Family: Serine protease inhibitor
• UniProt Gene Name: SERPINA6
• UniProt Synonym Gene Names: CBG; CBG
• UniProt Entry Name: CBG_HUMAN

NCBI Description

This gene encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors which may have evolved by duplication events. [provided by RefSeq, Jul 2008]

Uniprot Description

SERPINA6: Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species. Defects in SERPINA6 are a cause of corticosteroid-binding globulin deficiency (CBG deficiency). CBG deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo/hypertension and muscle fatigue. Belongs to the serpin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 14q32.1

Cellular Component: extracellular space

Molecular Function: serine-type endopeptidase inhibitor activity; steroid binding

Biological Process: glucocorticoid metabolic process; transport

Disease: Corticosteroid-binding Globulin Deficiency