Rabbit SERPINA12 Polyclonal Antibody | anti-SERPINA12 antibody

SERPINA12 Antibody HRP Conjugated

Cat. Num. AAA9461819

• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: Purified by Protein A
• Synonyms: SERPINA12; Polyclonal Antibody; SERPINA12 Antibody HRP Conjugated; OL 64; OL-64; OL64; Serine or cysteine proteinase inhibitor clade A alpha 1 antiproteinase antitrypsin member 12 ; Serpin A12; Serpin A12 precursor; Serpin peptidase inhibitor clade A alpha 1 antiproteinase antitrypsin member 12; Serpina12; SPA12_HUMAN antibody Vaspin; Visceral adipose specic serpin; anti-SERPINA12 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A
• Form/Format: 10mM Tris Buffered Saline containing 1% BSA, 50% glycerol and 0.09% Gentamicin.
• Concentration: 1mgml (varies by lot)

• Applicable Applications for anti-SERPINA12 antibody: Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: WB: 1:100-1000; IHC: 1:100-500
• Conjugation: HRP
• Immunogen: KLH conjugated synthetic peptide derived from human SERPINA12 Vaspin
• Preparation and Storage: Store at 4 degree C for 12 months.

Related Product Information for anti-SERPINA12 antibody

May modulates insulin action conceivably only in the presence of its yet undefined target proteases in white adipose tissues.Serpins are the largest and most diverse family of protease inhibitors. Most serpins control proteolytic cascades, certain serpins do not inhibit enzymes, but instead perform diverse functions such as storage (ovalbumin, in egg white), hormone carriage proteins (thyroxine-binding globulin, cortisol-binding globulin) and tumor suppressor genes (maspin). Most inhibitory serpins target chymotrypsin-like serine proteases. These enzymes are defined by the presence of a nucleophilic serine residue in their catalytic site. Some serpins inhibit other classes of protease. A number of such serpins have been shown to target cysteine proteases. These enzymes differ from serine proteases in that they are defined by the presence of a nucleophilic cysteine residue, rather than a serine residue, in their catalytic site. SerpinA12, also known as OL-64, Visceral adipose tissue-derived serine protease inhibitor, Vaspin, Visceral adipose-specific serpin and SERPINA12, is a secreted protein which belongs to the serpin family. SerpinA12 Vaspin is expressed in visceral adipose tissues. It may modulates insulin action conceivably only in the presence of its yet undefined target proteases in white adipose tissues. SerpinA12 Vaspin may be the compensatory molecule in the pathogenesis of metabolic syndrome and SerpinA12 Vaspin recombinant protein or vaspin-mimicking agents such as vaspin analogs, or small molecule agents may be the link to drug discovery and development.

Product Categories/Family for anti-SERPINA12 antibody

Conjugated Primary Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 27777657
• NCBI Accession #: NP_776249.1
• NCBI GenBank Nucleotide #: NP_776249.1
• UniProt Accession #: Q8IW75
• NCBI Official Full Name: serpin A12
• UniProt Protein Name: Serpin A12
• Protein Family: Serpin
• UniProt Gene Name: SERPINA12
• UniProt Synonym Gene Names: Vaspin
• UniProt Entry Name: SPA12_HUMAN

Uniprot Description

SERPINA12: May modulate insulin action conceivably only in the presence of its yet undefined target proteases in white adipose tissues. Belongs to the serpin family.

Protein type: Inhibitor; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 14q32.13

Cellular Component: extracellular space; plasma membrane

Molecular Function: serine-type endopeptidase inhibitor activity

Biological Process: positive regulation of phosphoinositide 3-kinase cascade; negative regulation of lipid biosynthetic process; negative regulation of gluconeogenesis; positive regulation of insulin receptor signaling pathway