Rabbit anti-Human Serpin A5 Polyclonal Antibody | anti-SerpinA5 antibody

Anti-Serpin A5 Antibody, Rabbit Polyclonal

Cat. Num. AAA8102215

• Gene Names: SERPINA5; PCI; PAI3; PAI-3; PCI-B; PROCI; PLANH3
• Reactivity: Human
• Applications: ELISA
• Purity: Protein A
• Synonyms: Serpin A5; Polyclonal Antibody; Anti-Serpin A5 Antibody; Rabbit Polyclonal; SerpinA5 Antibody; Rabbit PAb; serpin peptidase inhibitor; clade A (alpha-1 antiproteinase; antitrypsin); member 5; Anti-PAI-3 Antibody; Anti-PAI3 Antibody; Anti-PCI Antibody; Anti-PCI-B Antibody; Anti-PLANH3 Antibody; Anti-PROCI Antibody; Anti-Protein C Inhibitor Antibody; anti-SerpinA5 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Human SerpinA5/Protein C inhibitor
• Purity/Purification: Protein A
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-SerpinA5 antibody: ELISA (EIA)
• Application Notes: ELISA: 1:1000-1:2000
• Immunogen: Recombinant Human SerpinA5 protein
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with purified, recombinant Human SerpinA5 (rhSerpinA5). Total IgG was purified by Protein A affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-SerpinA5 antibody

Serpin A5, also well known as protein C inhibitor (PCI), is a member of the human serpin superfamily that consists of at least 35 members. It is synthesized in the liver and has been detected in saliva, cerebral spinal fluid, amniotic fluid, tears and semen. As a potent inhibitor of the protein C anticoagulant pathway at the levels of both zymogen activation and enzyme inhibition, serpinA5 additionally inhibits a variety of serine protease including thrombin, factor Xa, several kallekreins and acrosin, and plays a role in the processes of blood coagulation and fertilization. Serpin A5 also inhibits urinary plasminogen activator (uPA), a mediator of tumor cell invasion, and regulates tumor growth and metastasis by inhibiting angiogenesis. Furthermore, recent studies have identified PCI as a potent and direct inhibitor of activated HGFA (hepatocyte growth factor activator), suggesting a novel function in the regulation of tissue repair and regeneration. Similar to serpins C1 and D1, the thrombin inhibitory activity of serpinA5 is enhanced by heparin.

References

Alireza, R. et al., 1995, J. Biol. Chem. 270: 25336-25339. Silverman, G.A. et al., 2001, J. Biol. Chem. 276: 33293-33296. Malleier, J.M. et al., 2007, Blood. 109: 4769-4776. Asanuma, K. et al., 2007, Int. J. Cancer. 121: 955-965. Hayashi, T. et al., 2007, J. Thromb. Haemost. 5: 1477-1485.

NCBI and Uniprot Product Information

• NCBI GI #: 194018472
• NCBI GeneID: 5104
• NCBI Accession #: NP_000615.3
• NCBI GenBank Nucleotide #: NM_000624.5
• UniProt Accession #: P05154; Q07616; Q9UG30
• Molecular Weight: 45,675 Da
• NCBI Official Full Name: plasma serine protease inhibitor preproprotein
• NCBI Official Synonym Full Names: serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
• NCBI Official Symbol: SERPINA5
• NCBI Official Synonym Symbols: PCI; PAI3; PAI-3; PCI-B; PROCI; PLANH3
• NCBI Protein Information: plasma serine protease inhibitor; serpin A5; protein C inhibitor; plasminogen activator inhibitor-3; acrosomal serine protease inhibitor; plasminogen activator inhibitor III; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, anti
• UniProt Protein Name: Plasma serine protease inhibitor
• Protein Family: Plasma serine protease inhibitor
• UniProt Gene Name: SERPINA5
• UniProt Synonym Gene Names: PCI; PLANH3; PROCI; PAI-3; PAI3; PCI
• UniProt Entry Name: IPSP_HUMAN

NCBI Description

The protein encoded by this gene is a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. This gene is one in a cluster of serpin genes located on the q arm of chromosome 14. This family member is a glycoprotein that can inhibit several serine proteases, including protein C and various plasminogen activators and kallikreins, and it thus plays diverse roles in hemostasis and thrombosis in multiple organs. [provided by RefSeq, Aug 2012]

Uniprot Description

SERPINA5: Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extravascular proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and proinflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin complex. Acts as an anticoagulant factor by inhibiting blood coagulation factors like prothrombin, factor XI, factor Xa, plasma kallikrein and fibrinolytic enzymes such as tissue- and urinary- type plasminogen activators. In seminal plasma, inactivates several serine proteases implicated in the reproductive system. Inhibits the serpin acrosin; indirectly protects component of the male genital tract from being degraded by excessive released acrosin. Inhibits tissue-and urinary-type plasminogen activator, prostate-specific antigen and kallikrein activities; has a control on the sperm motility and fertilization. Inhibits the activated protein C-catalyzed degradation of SEMG1 and SEMG2; regulates the degradation of semenogelin during the process of transfer of spermatozoa from the male reproductive tract into the female tract. In urine, inhibits urinary-type plasminogen activator and kallikrein activities. Inactivates membrane-anchored serine proteases activities such as MPRSS7 and TMPRSS11E. Inhibits urinary-type plasminogen activator-dependent tumor cell invasion and metastasis. May also play a non-inhibitory role in seminal plasma and urine as an hydrophobic hormone carrier by its binding to retinoic acid. Belongs to the serpin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 14q32.1

Cellular Component: extracellular space; protein complex; membrane; extracellular region; acrosomal membrane; external side of plasma membrane

Molecular Function: acrosin binding; heparin binding; serine-type endopeptidase inhibitor activity; glycosaminoglycan binding; retinoic acid binding; protease binding; phosphatidylcholine binding

Biological Process: fusion of sperm to egg plasma membrane; spermatogenesis; lipid transport; blood coagulation