Serine/Threonine-Protein Kinase US3 Homolog Polyclonal Antibody | anti-US3 antibody
Serine/Threonine-Protein Kinase US3 Homolog Polyclonal Antibody
NCBI and Uniprot Product Information
Uniprot Description
Function: Multifunctional serine/threonine kinase that plays a role in several processes including egress of virus particles from the nucleus, modulation of the actin cytoskeleton and inhibition of apoptosis. Phosphorylates proteins 24 and 27, two critical regulators of capsid budding from nucleus to endoplasmic reticulum, thereby facilitating virion egress. Modulates and redistributes host components of the nuclear envelope, including LMNA, emerin/EMD and the nuclear matrix protein MATR3. Phosphorylates envelope glycoprotein B (gB), probably to direct it to the cell surface. Promotes virus intracellular spread by restructuring host cell cytoskeleton. Blocks host apoptosis to extend cell survival and allow efficient viral replication. Promotes viral gene expression by phosphorylating host HDAC2 to reduce viral genome silencing
By similarity. Downregulates class I major histocompatibility complex (MHC-I) surface expression. Additionally, phosphorylates IE62 and targets it to the cytoplasm. The nuclear exclusion of IE62 enables the packaging of abundant levels of IE62 into virions. Ref.5 Ref.6 Ref.7 Ref.8
Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
Subcellular location: Host cytoplasm
By similarity. Host nucleus
By similarity.
Post-translational modification: Phosphorylated by ORF47; this phosphorylation regulates subsequent phosphorylation of proteins 24 and 27 by ORF66. Autophosphorylated
By similarity. Ref.4 Ref.8
Sequence similarities: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.Contains 1 protein kinase domain.
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Product Notes
The US3 66 (Catalog #AAA8537543) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Serine/Threonine-Protein Kinase US3 Homolog Polyclonal Antibody reacts with Varicella-zoster virus (strain Dumas) (HHV-3) and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "Serine/Threonine-Protein Kinase US3 Homolog, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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