Structure
(Structure of G9951-25.)
GW2580, Free Base, Inhibitor
GW2580, Free Base (5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine)
Purity
Highly Purified~99%
Synonyms
GW2580; Free Base; Free Base (5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2; 4-diamine); inhibitor
Purity/Purification
Highly Purified
~99%
~99%
Form/Format
Supplied as an off-white powder
CAS Number
870483-87-7
Molecular Formula
C20H22N4O3
Elemental Analysis
Calculated
C = 65.56%
H = 6.05%
N = 15.29%
Found C = ~65% H = ~6% N = ~15%
C = 65.56%
H = 6.05%
N = 15.29%
Found C = ~65% H = ~6% N = ~15%
Melting Point
209-210.5 degree C
Solubility
Soluble in DMSO at 40mg/ml; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 20-100uM; buffers, serum, or other additives may increase or decrease the aqueous solubility.
Preparation and Storage
Long-term storage is recommended at -20 degree C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Structure
(Structure of G9951-25.)
Structure
(Structure of G9951-25.)
Related Product Information for GW2580, Free Base, inhibitor
GW2580 is a small-molecule inhibitor of cFMS kinase; at 60nM it inhibited human cFMS kinase completely in vitro and was inactive against 26 other kinases. GW2580 inhibited lipopolysaccharide (LPS)-induced TNF production in mice, but not LPS-induced TNF production in freshly isolated human monocytes and mouse macrophages in vitro. Also, GW2580 at 1uM totally inhibited CSF-1-induced growth of mouse M-NFS-60 myeloid cells and human monocytes, and prevented bone degradation in cultures of rat calvaria and rat fetal long bone in vitro.
Product Categories/Family for GW2580, Free Base, inhibitor
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Product Notes
The GW2580, Free Base (Catalog #AAA655364) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "GW2580, Free Base, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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