Rabbit SEPW1 Polyclonal Antibody | anti-SEPW1 antibody

SEPW1 Polyclonal Antibody

Cat. Num. AAA2561364

• Gene Names: SELENOW; selW; SEPW1
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, ELISA
• Purity: Antigen Affinity Purification
• Synonyms: SEPW1; Polyclonal Antibody; SEPW1 Polyclonal Antibody; Selenoprotein W; SELW; anti-SEPW1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purification
• Form/Format: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
• Concentration: 0.7mg/mL (varies by lot)
• Sequence Length: 87

• Applicable Applications for anti-SEPW1 antibody: Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: IHC: 1:25-1:100; ELISA: 1:5000-1:10000
• Immunogen: Synthetic peptide of human SEPW1
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using SEPW1 Polyclonal Antibody at dilution of 1:25(×200))

Related Product Information for anti-SEPW1 antibody

This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is highly expressed in skeletal muscle, heart and brain. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Studies in mouse show that this selenoprotein is involved in muscle growth and differentiation, and in the protection of neurons from oxidative stress during neuronal development. A retroprocessed pseudogene of this locus has been identified on chromosome 1.

NCBI and Uniprot Product Information

• NCBI GI #: 4506887
• NCBI GeneID: 6415
• NCBI Accession #: NP_003000.1
• NCBI GenBank Nucleotide #: NP_003000.1
• UniProt Accession #: P63302
• NCBI Official Full Name: selenoprotein W
• NCBI Official Synonym Full Names: selenoprotein W
• NCBI Official Symbol: SELENOW
• NCBI Official Synonym Symbols: selW; SEPW1
• NCBI Protein Information: selenoprotein W
• UniProt Protein Name: Selenoprotein W
• Protein Family: Selenoprotein
• UniProt Gene Name: SEPW1
• UniProt Synonym Gene Names: SELW; SelW
• UniProt Entry Name: SELW_HUMAN

NCBI Description

This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is highly expressed in skeletal muscle, heart and brain. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Studies in mouse show that this selenoprotein is involved in muscle growth and differentiation, and in the protection of neurons from oxidative stress during neuronal development. A retroprocessed pseudogene of this locus has been identified on chromosome 1. [provided by RefSeq, Aug 2017]

Uniprot Description

SEPW1: Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency. Belongs to the SelWTH family. SELW subfamily.

Chromosomal Location of Human Ortholog: 19q13.3