Immunohistochemistry (IHC)
Rabbit SEPT4 Polyclonal Antibody | anti-SEPT4 antibody
Anti-SEPT4 Antibody
Western blot analysis: 1:1,000-1:2,000
Immunohistochemistry: 1:100-1:500
Optimal dilutions/concentrations should be determined by the end user.
Immunohistochemistry (IHC)
Immunohistochemistry (IHC)
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. One of the isoforms (known as ARTS) is distinct; it is localized to the mitochondria, and has a role in apoptosis and cancer. [provided by RefSeq, Nov 2010]
Uniprot Description
SEPT4: Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli. Belongs to the septin family. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Apoptosis; Cell development/differentiation; Cytoskeletal; Hydrolase
Chromosomal Location of Human Ortholog: 17q22
Cellular Component: cytoskeleton; mitochondrion; nucleus
Molecular Function: GTPase activity; protein binding; GTP binding; structural molecule activity
Biological Process: regulation of apoptosis; sperm mitochondrion organization and biogenesis; apoptosis; positive regulation of protein ubiquitination; positive regulation of apoptosis; cell division; metabolic process; brain development; cell cycle; sperm capacitation
Research Articles on SEPT4
Similar Products
Product Notes
The SEPT4 sept4 (Catalog #AAA415676) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-SEPT4 Antibody reacts with Human. Not yet tested in other species and may cross-react with other species as described in the data sheet. AAA Biotech's SEPT4 can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA), Western Blot, Immunohistochemistry (IHC). Peptide ELISA titer: 1:10,000-1:40,000 Western blot analysis: 1:1,000-1:2,000 Immunohistochemistry: 1:100-1:500 Optimal dilutions/concentrations should be determined by the end user. Researchers should empirically determine the suitability of the SEPT4 sept4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SEPT4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
