Rabbit anti-Human Secretogranin II Polyclonal Antibody | anti-SCG2 antibody

Anti-Secretogranin II Antibody, Rabbit Polyclonal

Cat. Num. AAA8103409

• Gene Names: SCG2; SN; CHGC; EM66; SgII
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Protein A & Antigen Affinity
• Synonyms: Secretogranin II; Polyclonal Antibody; Anti-Secretogranin II Antibody; Rabbit Polyclonal; SCG2/Secretogranin II Antibody; Rabbit PAb; Antigen Affinity Purified; secretogranin II; Anti-CHGC Antibody; Anti-EM66 Antibody; Anti-SgII Antibody; Anti-SN Antibody; anti-SCG2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Human SCG2/Secretogranin II
• Purity/Purification: Protein A & Antigen Affinity
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-SCG2 antibody: Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: IHC-P: 1:500-1:2000
• Immunogen: A synthetic peptide corresponding to the center region of the Human SCG2/Secretogranin II
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with a synthetic peptide corresponding to the center region of the Human SCG2/Secretogranin II, and purified by antigen affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunochemical staining of human SCG2 in human pancreas with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.)

Related Product Information for anti-SCG2 antibody

Kit ligand, also known as Hematopoietic growth factor KL, Mast cell growth factor, Steel factor, Stem cell factor, c-Kit ligand, Kitlg and KITL, is a single-pass type I membrane protein that belongs to the SCF family. KITL/kit ligand also belongs to the family of dimeric transmembrane growth factors. The soluble form of KIT ligand is a secreted protein. Mast cells are thought to participate in a variety of immune responses, such as parasite resistance and the allergic reaction. Mast cell development depends on stem cell factor (Kit ligand) and its receptor, c-Kit. KITL/kit ligand stimulates the proliferation of mast cells. KITL/kit ligand is able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Efficient cell surface presentation of KITL/kit ligand is essential for the migration, proliferation, and survival of melanocytes, germ cells, hemopoietic stem cells, and mastocytes. KITL/kit ligand acts synergistically with other cytokines, probably interleukins. KITL/kit ligand plays a crucial role in the development and maintenance of the melanocyte lineage in adult skin. It exerts permanent survival, proliferation and migration functions in Kit receptor-expressing melanocytes. KITL/kit ligand misexpression in some hyperpigmented lesions may open the avenue for Kitl-dependent treatment of pathological skin conditions.

References

Nishida, K.et al., 2002, Blood. 99 (5):1866-9. Paulhe, F. et al., 2004, J Biol Chem. 279 (53):55545-55. Fernandez, S.M. et al., 2008, Biol Reprod. 79 (2):318-27. Wehrle-Haller, B. et al., 2003, Pigment Cell Res.16 (3):287-96.

NCBI and Uniprot Product Information

• NCBI GI #: 68160947
• NCBI GeneID: 7857
• NCBI Accession #: NP_003460.2
• NCBI GenBank Nucleotide #: NM_003469.4
• UniProt Accession #: P13521; Q53T11; Q8TBH3; B2R662
• Molecular Weight: 70,941 Da
• NCBI Official Full Name: secretogranin-2
• NCBI Official Synonym Full Names: secretogranin II
• NCBI Official Symbol: SCG2
• NCBI Official Synonym Symbols: SN; CHGC; EM66; SgII
• NCBI Protein Information: secretogranin-2; secretoneurin; chromogranin-C
• UniProt Protein Name: Secretogranin-2
• Protein Family: Secretogranin
• UniProt Gene Name: SCG2
• UniProt Synonym Gene Names: CHGC; SgII; SN
• UniProt Entry Name: SCG2_HUMAN

NCBI Description

The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown. [provided by RefSeq, Jul 2008]

Uniprot Description

SCG2: Secretogranin-2 is a neuroendocrine secretory granule protein, which is the precursor for biologically active peptides. Belongs to the chromogranin/secretogranin protein family.

Protein type: Apoptosis; Secreted, signal peptide; Cell cycle regulation; Cytokine; Motility/polarity/chemotaxis; Secreted

Chromosomal Location of Human Ortholog: 2q35-q36

Cellular Component: extracellular space; secretory granule

Molecular Function: cytokine activity; chemoattractant activity

Biological Process: positive chemotaxis; negative regulation of endothelial cell proliferation; MAPKKK cascade; protein secretion; eosinophil chemotaxis; endothelial cell migration; positive regulation of endothelial cell proliferation; angiogenesis; inflammatory response; induction of positive chemotaxis