Mouse anti-Human SEC23IP Polyclonal Antibody | anti-SEC23IP antibody

SEC23IP (SEC23-interacting Protein, MSTP053, p125, P125A)

Cat. Num. AAA647740

• Gene Names: SEC23IP; P125; P125A; MSTP053
• Reactivity: Human
• Applications: Western Blot, Immunofluorescence
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: SEC23IP; Polyclonal Antibody; SEC23IP (SEC23-interacting Protein; MSTP053; p125; P125A); Anti -SEC23IP (SEC23-interacting Protein; anti-SEC23IP antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human SEC23IP.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.

• Applicable Applications for anti-SEC23IP antibody: Western Blot (WB), Immunofluorescence (IF)
• Application Notes: Suitable for use in Immunofluorescence and Western Blot.; Dilution: Immunofluorescence: 10ug/ml
• Immunogen: Full length human EC23IP, aa1-486 (N/A).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of SEC23IP expression in transfected 293T cell line by SEC23IP polyclonal antibody. Lane 1: SEC23IP transfected lysate (53.46kD). Lane 2: Non-transfected lysate.)

Immunofluorescence (IF)

(Immunofluorescence of purified antibody to SEC23IP on HeLa cell. [antibody concentration 10ug/ml])

Product Categories/Family for anti-SEC23IP antibody

Antibodies; Abs to Transport Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 6005824
• NCBI GeneID: 11196
• NCBI Accession #: NP_009121.1
• NCBI GenBank Nucleotide #: NM_007190.3
• UniProt Accession #: Q9Y6Y8; Q8IXH5; Q9BUK5; D3DRD2
• Molecular Weight: 111,076 Da
• NCBI Official Full Name: SEC23-interacting protein
• NCBI Official Synonym Full Names: SEC23 interacting protein
• NCBI Official Symbol: SEC23IP
• NCBI Official Synonym Symbols: P125; P125A; MSTP053
• NCBI Protein Information: SEC23-interacting protein
• UniProt Protein Name: SEC23-interacting protein
• Protein Family: SEC23-interacting protein
• UniProt Gene Name: SEC23IP
• UniProt Entry Name: S23IP_HUMAN

NCBI Description

This gene encodes a member of the phosphatidic acid preferring-phospholipase A1 family. The encoded protein is localized to endoplasmic reticulum exit sites and plays a critical role in ER-Golgi transport as part of the multimeric coat protein II complex. An orthologous gene in frogs is required for normal neural crest cell development, suggesting that this gene may play a role in Waardenburg syndrome neural crest defects. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011]

Uniprot Description

Function: Plays a role in the organization of endoplasmic reticulum exit sites. Specifically binds to phosphatidylinositol 3-phosphate (PI3P), phosphatidylinositol 4-phosphate (PI4P) and phosphatidylinositol 5-phosphate (PI5P). Ref.1 Ref.7 Ref.11

Subunit structure: Interacts with SEC23A. Ref.1

Subcellular location: Cytoplasmic vesicle › COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum

Probable Ref.1 Ref.7.

Tissue specificity: Ubiquitously expressed with stronger levels detected in heart, liver and skeletal muscle. Ref.1

Sequence similarities: Belongs to the PA-PLA1 family.Contains 1 DDHD domain.Contains 1 SAM (sterile alpha motif) domain.

Caution: Although belonging to the PA-PL1 family, does not seem to have any phospholipase activity.

Sequence caution: The sequence AAP35401.1 differs from that shown. Reason: Frameshift at position 471.