Rabbit anti-Mouse SEC14L2 Polyclonal Antibody | anti-SEC14L2 antibody

SEC14L2, NT (SEC14L2, C22orf6, KIAA1186, KIAA1658, SEC14-like protein 2, Alpha-tocopherol-associated protein, Squalene transfer protein, Supernatant protein factor) (APC)

Cat. Num. AAA6345724

• Gene Names: SEC14L2; SPF; TAP; TAP1; C22orf6
• Reactivity: Mouse
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: SEC14L2; Polyclonal Antibody; NT (SEC14L2; C22orf6; KIAA1186; KIAA1658; SEC14-like protein 2; Alpha-tocopherol-associated protein; Squalene transfer protein; Supernatant protein factor) (APC); Supernatant protein factor; anti-SEC14L2 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).
• Sequence Length: 403

• Applicable Applications for anti-SEC14L2 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: SEC14L2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 40-69 amino acids from the N-terminal region of human SEC14L2.
• Conjugate: APC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(SEC14L2 Antibody (N-term) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the SEC14L2 antibody detected the SEC14L2 protein (arrow).)

Related Product Information for anti-SEC14L2 antibody

This gene encodes a cytosolic protein which belongs to a family of lipid-binding proteins including Sec14p, alpha-tocopherol transfer protein, and cellular retinol-binding protein. The encoded protein stimulates squalene monooxygenase which is a downstream enzyme in the cholesterol biosynthetic pathway. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Product Categories/Family for anti-SEC14L2 antibody

Antibodies; KIAA; orf

References

Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010). Wang, X., et al. Cancer Invest. 27(10):971-977(2009). Hosgood, H.D. III, et al. Respir Med 103(12):1866-1870(2009). Johnykutty, S., et al. Mod. Pathol. 22(6):770-775(2009). Wright, M.E., et al. Cancer Res. 69(4):1429-1438(2009).

NCBI and Uniprot Product Information

• NCBI GI #: 7110715
• NCBI GeneID: 23541
• NCBI Accession #: NP_036561.1; NP_203740.1
• NCBI GenBank Nucleotide #: NP_036561.1
• UniProt Accession #: O76054
• NCBI Official Full Name: SEC14-like protein 2 isoform 1
• NCBI Official Synonym Full Names: SEC14 like lipid binding 2
• NCBI Official Symbol: SEC14L2
• NCBI Official Synonym Symbols: SPF; TAP; TAP1; C22orf6
• NCBI Protein Information: SEC14-like protein 2
• UniProt Protein Name: SEC14-like protein 2
• Protein Family: SEC14-like protein
• UniProt Gene Name: SEC14L2
• UniProt Synonym Gene Names: C22orf6; KIAA1186; KIAA1658; TAP; hTAP; SPF
• UniProt Entry Name: S14L2_HUMAN

NCBI Description

This gene encodes a cytosolic protein which belongs to a family of lipid-binding proteins including Sec14p, alpha-tocopherol transfer protein, and cellular retinol-binding protein. The encoded protein stimulates squalene monooxygenase which is a downstream enzyme in the cholesterol biosynthetic pathway. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]

Uniprot Description

SEC14L2: Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Lipid-binding

Chromosomal Location of Human Ortholog: 22q12.2

Cellular Component: cytoplasm; integral to membrane; nucleus

Molecular Function: transporter activity; phospholipid binding; vitamin E binding

Biological Process: transcription, DNA-dependent; transport; regulation of cholesterol biosynthetic process; positive regulation of transcription, DNA-dependent