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Western Blot (WB) (Western Blot (WB) analysis of SDCCAG8 polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysateLane2:RAW264. 7 whole cell lysate Lane3:H9C2 whole cell lysate)

Rabbit SDCCAG8 Polyclonal Antibody | anti-SDCCAG8 antibody

SDCCAG8 Polyclonal Antibody

Gene Names
SDCCAG8; BBS16; CCCAP; SLSN7; NPHP10; hCCCAP; HSPC085; NY-CO-8; CCCAP SLSN7
Reactivity
Human, Mouse, Rat
Applications
Western Blot
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Synonyms
SDCCAG8; Polyclonal Antibody; SDCCAG8 Polyclonal Antibody; Serologically defined colon cancer antigen 8; Antigen NY-CO-8; Centrosomal colon cancer autoantigen protein; hCCCAP; CCCAP; NPHP10; anti-SDCCAG8 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
SDCCAG8 polyclonal antibody detects endogenous levels of SDCCAG8 protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Form/Format
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Sequence Length
713
Applicable Applications for anti-SDCCAG8 antibody
Western Blot (WB)
Application Notes
WB: 1:500-1:1000
Immunogen
A synthetic peptide corresponding to residues in Human SDCCAG8.
Preparation and Storage
Store at 4 degree C short term.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of SDCCAG8 polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysateLane2:RAW264. 7 whole cell lysate Lane3:H9C2 whole cell lysate)

Western Blot (WB) (Western Blot (WB) analysis of SDCCAG8 polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysateLane2:RAW264. 7 whole cell lysate Lane3:H9C2 whole cell lysate)
Related Product Information for anti-SDCCAG8 antibody
SDCCAG8 (serologically defined colon cancer antigen 8), also known as CCCAP (centrosomal colon cancer autoantigen protein), HSPC085 or NY-CO-8, is a 713 amino acid cytoplasmic protein that is expressed in thymus, prostate, testis, ovary, small intestine, colon, mucosa and renal cancer tumors. Existing as a homodimer, SDCCAG8 localizes to centrioles and interacts with oral-facial-digital syndrome 1 (ODF1), which is associated with nephronophthisis-related ciliopathies (NPHP-RC), a recessive disorder that is characterized by dysplasia or degeneration of the kidney, retina and cerebellum. SDCCAG8 exists as four alternatively spliced isoforms and is encoded by a gene located on humanc chromosome 1, which spans 260 million base pairs, contains over 3, 000 genes and comprises nearly 8% of the human genome.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
~ 41kDa
NCBI Official Full Name
serologically defined colon cancer antigen 8 isoform 1
NCBI Official Synonym Full Names
SHH signaling and ciliogenesis regulator SDCCAG8
NCBI Official Symbol
SDCCAG8
NCBI Official Synonym Symbols
BBS16; CCCAP; SLSN7; NPHP10; hCCCAP; HSPC085; NY-CO-8; CCCAP SLSN7
NCBI Protein Information
serologically defined colon cancer antigen 8
UniProt Protein Name
Serologically defined colon cancer antigen 8
UniProt Gene Name
SDCCAG8
UniProt Synonym Gene Names
CCCAP; NPHP10; hCCCAP
UniProt Entry Name
SDCG8_HUMAN

NCBI Description

This gene encodes a centrosome associated protein. This protein may be involved in organizing the centrosome during interphase and mitosis. Mutations in this gene are associated with retinal-renal ciliopathy. [provided by RefSeq, Oct 2010]

Uniprot Description

SDCCAG8: Plays a role in the establishment of cell polarity and epithelial lumen formation. May play a role in ciliogenesis. Defects in SDCCAG8 are the cause of Senior-Loken syndrome type 7 (SLSN7). SLSN7 is a renal-retinal disorder characterized by progressive wasting of the filtering unit of the kidney (nephronophthisis), with or without medullary cystic renal disease, and progressive eye disease. Typically this disorder becomes apparent during the first year of life. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 1q43

Cellular Component: centriole; centrosome; intercellular junction; cytosol

Molecular Function: protein binding

Biological Process: establishment of cell polarity; organelle organization and biogenesis; lumen formation; mitotic cell cycle; G2/M transition of mitotic cell cycle

Disease: Bardet-biedl Syndrome 16; Bardet-biedl Syndrome 1; Senior-loken Syndrome 7

Research Articles on SDCCAG8

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Product Notes

The SDCCAG8 sdccag8 (Catalog #AAA3007204) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SDCCAG8 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's SDCCAG8 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:500-1:1000. Researchers should empirically determine the suitability of the SDCCAG8 sdccag8 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SDCCAG8, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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