Western Blot (WB)
(SCN5A Antibody (N-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the SCN5A antibody detected the SCN5A protein (arrow).)
Rabbit SCN5A Polyclonal Antibody | anti-SCN5A antibody
SCN5A Antibody (N-term)
Western Blot (WB)
(SCN5A Antibody (N-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the SCN5A antibody detected the SCN5A protein (arrow).)
Western Blot (WB)
(SCN5A Antibody (N-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the SCN5A antibody detected the SCN5A protein (arrow).)
protein and tetrodotoxin-resistant voltage-gated sodium channel
subunit. This protein is found primarily in cardiac muscle and is
responsible for the initial upstroke of the action potential in an
electrocardiogram. Defects in this gene are a cause of long QT
syndrome type 3 (LQT3), an autosomal dominant cardiac disease.
Alternative splicing results in several transcript variants
encoding different isoforms.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
van Stuijvenberg, L., et al. DNA Cell Biol. 29(10):577-587(2010)
House, C.D., et al. Cancer Res. 70(17):6957-6967(2010)
Garcia-Castro, M., et al. Rev Esp Cardiol 63(7):856-859(2010)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Description
SCN5A: an integral membrane protein and a voltage-gated sodium channel subunit. Mediates the voltage-dependent sodium ion permeability of excitable membranes. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na(+) channel isoform. Intracellular calcium levels regulate channel inactivation. Interacts with the PDZ domain of the syntrophin SNTA1, SNTB1 and SNTB2. Interacts with NEDD4, NEDD4L, WWP2 and GPD1L. Defects in this protein are a cause of long QT syndrome type 3 (LQT3). Belongs to the sodium channel (TC 1.A.1.10) family, Nav1.5/SCN5A subfamily. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Channel, sodium; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 3p21
Cellular Component: voltage-gated sodium channel complex; cell surface; endoplasmic reticulum; T-tubule; plasma membrane; integral to membrane; caveola; sarcolemma; lateral plasma membrane
Molecular Function: calmodulin binding; protein binding; enzyme binding; fibroblast growth factor binding; ubiquitin protein ligase binding; voltage-gated sodium channel activity; ankyrin binding; nitric-oxide synthase binding; protein kinase binding
Biological Process: membrane depolarization; axon guidance; telencephalon development; regulation of heart rate; sodium ion transport; generation of action potential; cerebellum development; response to denervation involved in regulation of muscle adaptation; positive regulation of action potential; positive regulation of epithelial cell proliferation; cardiac muscle contraction; odontogenesis of dentine-containing teeth
Disease: Brugada Syndrome 1; Sudden Infant Death Syndrome; Ventricular Fibrillation During Myocardial Infarction, Susceptibility To; Sick Sinus Syndrome 1, Autosomal Recessive; Progressive Familial Heart Block, Type Ia; Long Qt Syndrome 3; Cardiomyopathy, Dilated, 1e; Atrial Fibrillation, Familial, 10
Research Articles on SCN5A
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Product Notes
The SCN5A scn5a (Catalog #AAA9205102) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 42-70. The SCN5A Antibody (N-term) reacts with Human (Predicted Reactivity: Mouse, Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's SCN5A can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the SCN5A scn5a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SCN5A, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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