Rabbit SCN5A Polyclonal Antibody | anti-SCN5A antibody

SCN5A Polyclonal Antibody

Cat. Num. AAA2518032

• Gene Names: SCN5A; HB1; HB2; HH1; IVF; VF1; HBBD; ICCD; LQT3; SSS1; CDCD2; CMD1E; CMPD2; PFHB1; Nav1.5
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: SCN5A; Polyclonal Antibody; SCN5A Polyclonal Antibody; HB1; HB2; HH1; IVF; VF1; HBBD; ICCD; LQT3; SSS1; CDCD2; CMD1E; CMPD2; PFHB1; Nav1.5; anti-SCN5A antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 1.1mg/mL (varies by lot)
• Sequence Length: 1983

• Applicable Applications for anti-SCN5A antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:25-1:100
• Immunogen: Synthetic peptide of human SCN5A
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human breast cancer tissue using SCN5A Polyclonal Antibody at dilution 1:30)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using SCN5A Polyclonal Antibody at dilution 1:30)

Related Product Information for anti-SCN5A antibody

The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms.

Product Categories/Family for anti-SCN5A antibody

Neuroscience

NCBI and Uniprot Product Information

• NCBI GI #: 237512980
• NCBI GeneID: 6331
• NCBI Accession #: NP_001153632.1
• NCBI GenBank Nucleotide #: NM_001160160.1
• Molecular Weight: 224,917 Da
• NCBI Official Full Name: sodium channel protein type 5 subunit alpha isoform e
• NCBI Official Synonym Full Names: sodium channel, voltage gated, type V alpha subunit
• NCBI Official Symbol: SCN5A
• NCBI Official Synonym Symbols: HB1; HB2; HH1; IVF; VF1; HBBD; ICCD; LQT3; SSS1; CDCD2; CMD1E; CMPD2; PFHB1; Nav1.5
• NCBI Protein Information: sodium channel protein type 5 subunit alpha; cardiac tetrodotoxin-insensitive voltage-dependent sodium channel alpha subunit; sodium channel protein cardiac muscle subunit alpha; sodium channel, voltage-gated, type V, alpha subunit; voltage-gated sodium channel subunit alpha Nav1.5
• UniProt Protein Name: Sodium channel protein type 5 subunit alpha
• Protein Family: Sodium channel protein
• UniProt Gene Name: SCN5A
• UniProt Entry Name: SCN5A_HUMAN

NCBI Description

The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Description

SCN5A: an integral membrane protein and a voltage-gated sodium channel subunit. Mediates the voltage-dependent sodium ion permeability of excitable membranes. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na(+) channel isoform. Intracellular calcium levels regulate channel inactivation. Interacts with the PDZ domain of the syntrophin SNTA1, SNTB1 and SNTB2. Interacts with NEDD4, NEDD4L, WWP2 and GPD1L. Defects in this protein are a cause of long QT syndrome type 3 (LQT3). Belongs to the sodium channel (TC 1.A.1.10) family, Nav1.5/SCN5A subfamily. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, sodium

Chromosomal Location of Human Ortholog: 3p21

Cellular Component: voltage-gated sodium channel complex; cell surface; endoplasmic reticulum; T-tubule; integral to membrane; plasma membrane; caveola; sarcolemma; lateral plasma membrane

Molecular Function: calmodulin binding; protein binding; enzyme binding; fibroblast growth factor binding; ubiquitin protein ligase binding; voltage-gated sodium channel activity; ankyrin binding; nitric-oxide synthase binding; protein kinase binding

Biological Process: membrane depolarization; axon guidance; telencephalon development; regulation of heart rate; sodium ion transport; generation of action potential; cerebellum development; positive regulation of action potential; response to denervation involved in regulation of muscle adaptation; positive regulation of epithelial cell proliferation; odontogenesis of dentine-containing teeth; cardiac muscle contraction

Disease: Brugada Syndrome 1; Sudden Infant Death Syndrome; Ventricular Fibrillation During Myocardial Infarction, Susceptibility To; Sick Sinus Syndrome 1, Autosomal Recessive; Progressive Familial Heart Block, Type Ia; Long Qt Syndrome 3; Cardiomyopathy, Dilated, 1e; Atrial Fibrillation, Familial, 10