Rabbit anti-Human, Mouse SCN4B Polyclonal Antibody | anti-SCN4B antibody

SCN4B Rabbit Polyclonal

Cat. Num. AAA7603877

• Gene Names: SCN4B; LQT10; ATFB17; Navbeta4
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: SCN4B; Polyclonal Antibody; SCN4B Rabbit Polyclonal; anti-SCN4B antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 118

• Applicable Applications for anti-SCN4B antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Sodium channel, voltage-gated, type IV, beta
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human skeletal muscle tissue slide using MBS7603877 (SCN4B Antibody) at dilution of 1:50)

Western Blot (WB)

(mouse heart tissue were subjected to SDS PAGE followed by western blot with MBS7603877 (SCN4B antibody) at dilution of 1:500)

NCBI and Uniprot Product Information

• NCBI GI #: 215272334
• NCBI GeneID: 6330
• NCBI Accession #: NP_001135821.1
• NCBI GenBank Nucleotide #: NM_001142349.1
• Molecular Weight: 9,876 Da
• NCBI Official Full Name: sodium channel subunit beta-4 isoform 3
• NCBI Official Synonym Full Names: sodium voltage-gated channel beta subunit 4
• NCBI Official Symbol: SCN4B
• NCBI Official Synonym Symbols: LQT10; ATFB17; Navbeta4
• NCBI Protein Information: sodium channel subunit beta-4
• UniProt Protein Name: Sodium channel subunit beta-4
• Protein Family: Sodium channel
• UniProt Gene Name: SCN4B
• UniProt Entry Name: SCN4B_HUMAN

NCBI Description

The protein encoded by this gene is one of several sodium channel beta subunits. These subunits interact with voltage-gated alpha subunits to change sodium channel kinetics. The encoded transmembrane protein forms interchain disulfide bonds with SCN2A. Defects in this gene are a cause of long QT syndrome type 10 (LQT10). Three protein-coding and one non-coding transcript variant have been found for this gene.[provided by RefSeq, Mar 2009]

Uniprot Description

SCN4B: Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Defects in SCN4B are the cause of long QT syndrome type 10 (LQT10). Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress. They can present with a sentinel event of sudden cardiac death in infancy. Belongs to the sodium channel auxiliary subunit SCN4B (TC 8.A.17) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q23.3

Cellular Component: intrinsic to plasma membrane; voltage-gated sodium channel complex

Molecular Function: sodium channel regulator activity; voltage-gated sodium channel activity

Biological Process: cardiac muscle contraction; regulation of postsynaptic membrane potential; sodium ion transport

Disease: Long Qt Syndrome 10