Western Blot (WB)
(Western blot analysis of lysate from human skeletal muscle tissue lysate,using SCN4B Antibody. This antibody was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysate at 35ug.)
Rabbit SCN4B Polyclonal Antibody | anti-SCN4B antibody
SCN4B Antibody
Western Blot (WB)
(Western blot analysis of lysate from human skeletal muscle tissue lysate,using SCN4B Antibody. This antibody was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysate at 35ug.)
Western Blot (WB)
(Western blot analysis of lysate from human skeletal muscle tissue lysate,using SCN4B Antibody. This antibody was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysate at 35ug.)
Taylor T.D.,et al.Nature 440:497-500(2006).
Medeiros-Domingo A.,et al.Circulation 116:134-142(2007).
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is one of several sodium channel beta subunits. These subunits interact with voltage-gated alpha subunits to change sodium channel kinetics. The encoded transmembrane protein forms interchain disulfide bonds with SCN2A. Defects in this gene are a cause of long QT syndrome type 10 (LQT10). Three protein-coding and one non-coding transcript variant have been found for this gene.[provided by RefSeq, Mar 2009]
Uniprot Description
SCN4B: Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Defects in SCN4B are the cause of long QT syndrome type 10 (LQT10). Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress. They can present with a sentinel event of sudden cardiac death in infancy. Belongs to the sodium channel auxiliary subunit SCN4B (TC 8.A.17) family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 11q23.3
Cellular Component: voltage-gated sodium channel complex; intrinsic to plasma membrane
Molecular Function: sodium channel regulator activity; voltage-gated sodium channel activity
Biological Process: sodium ion transport; cardiac muscle contraction
Disease: Long Qt Syndrome 10
Research Articles on SCN4B
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Product Notes
The SCN4B scn4b (Catalog #AAA9205087) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 76-103. The SCN4B Antibody reacts with Human, mouse, rat and may cross-react with other species as described in the data sheet. AAA Biotech's SCN4B can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~ 1:1000. Researchers should empirically determine the suitability of the SCN4B scn4b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SCN4B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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