Rabbit SCN3A / Nav1.3 Polyclonal Antibody | anti-SCN3A antibody

Rabbit Polyclonal to Human SCN3A / Nav1.3

Cat. Num. AAA244627

• Gene Names: SCN3A; NAC3; Nav1.3
• Reactivity: Gorilla, Human; Predicted Reactivity: Gibbon, Monkey (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: SCN3A / Nav1.3; Polyclonal Antibody; Rabbit Polyclonal to Human SCN3A / Nav1.3; Anti-SCN3A / Nav1.3 Antibody (C-Terminus) IHC-plus; SCN3A; NAC3; Nav1.3; SCIII; Brain sodium channel III; KIAA1356; Human SCN3A; anti-SCN3A antibody

• Host: Rabbit
• Reactivity: Gorilla, Human; Predicted Reactivity: Gibbon, Monkey (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human SCN3A / Nav1.3. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: 20 mM PBS, 0.1% sodium azide.
• Sequence Length: 2000

• Applicable Applications for anti-SCN3A antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (25 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic 19 amino acid peptide from C-terminus of human SCN3A / Nav1.3. Percent identity with other species by BLAST analysis: Human, Gorilla, Marmoset (100%); Gibbon, Monkey (95%); Dog (89%); Panda, Bovine, Bat, Rabbit (84%).
• Immunogen Type: Synthetic peptide
• Immunogen: SCN3A / Nav1.3 antibody was raised against synthetic 19 amino acid peptide from C-terminus of human SCN3A / Nav1.3. Percent identity with other species by BLAST analysis: Human, Gorilla, Marmoset (100%); Gibbon, Monkey (95%); Dog (89%); Panda, Bovine, Bat, Rabbit (84%).
• Antigen Modification: C-Terminus
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-SCN3A / Nav1.3 antibody IHC of human spinal cord. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-SCN3A antibody

Scn3a encodes the alpha subunit of the type III voltage-gated sodium channel. These channels, composed of one alpha and one or two beta subunits, mediate changes in cell permeability to sodium ions that are essential for the generation of action potentials. The alpha subunit alone has been shown to generate a functional channel in vitro, but it's kinetic properties are modulated by beta subunits. The type III channel has been shown to be tetrodotoxin sensitive and fast inactivated.

Product Categories/Family for anti-SCN3A antibody

Family: Ion Channel; Subfamily: Sodium channel - voltage-gated

NCBI and Uniprot Product Information

• NCBI GI #: 126362949
• NCBI GeneID: 6328
• NCBI Accession #: NP_008853.3
• NCBI GenBank Nucleotide #: NM_006922.3
• UniProt Accession #: Q9NY46; Q16142; Q53SX0; Q9BZB3; Q9C006; Q9NYK2; Q9P2J1; Q9UPD1; Q9Y6P4
• Molecular Weight: 221,490 Da
• NCBI Official Full Name: sodium channel protein type 3 subunit alpha isoform 1
• NCBI Official Synonym Full Names: sodium channel, voltage-gated, type III, alpha subunit
• NCBI Official Symbol: SCN3A
• NCBI Official Synonym Symbols: NAC3; Nav1.3
• NCBI Protein Information: sodium channel protein type 3 subunit alpha; brain III voltage-gated sodium channel; voltage-gated sodium channel subtype III; sodium channel protein type III subunit alpha; sodium channel protein brain III subunit alpha; voltage-gated sodium channel subunit alpha Nav1.3; sodium channel, voltage-gated, type III, alpha polypeptide
• UniProt Protein Name: Sodium channel protein type 3 subunit alpha
• Protein Family: Sodium channel protein
• UniProt Gene Name: SCN3A
• UniProt Synonym Gene Names: KIAA1356; NAC3
• UniProt Entry Name: SCN3A_HUMAN

NCBI Description

Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is found in a cluster of five alpha subunit genes on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

SCN3A: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.3/SCN3A subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 2q24

Cellular Component: voltage-gated sodium channel complex; cytoplasm; plasma membrane

Molecular Function: voltage-gated sodium channel activity

Biological Process: sodium ion transport; generation of action potential