Western Blot (WB)
(Western blot detection of SCAI in C6,3T3 cell lysates using SCAI Rabbit pAb(1:1000 diluted). Predicted band size:70kDa. Observed band size:60kDa.)
Rabbit SCAI Polyclonal Antibody | anti-SCAI antibody
SCAI Rabbit pAb
IHC: 1:20
ICC/IF: 1:20
FC/FACS: 1:20
Western Blot (WB)
(Western blot detection of SCAI in C6,3T3 cell lysates using SCAI Rabbit pAb(1:1000 diluted). Predicted band size:70kDa. Observed band size:60kDa.)
Western Blot (WB)
(Western blot detection of SCAI in C6,3T3 cell lysates using SCAI Rabbit pAb(1:1000 diluted). Predicted band size:70kDa. Observed band size:60kDa.)
Tumor suppressor which functions to suppress MRTFA-induced SRF transcriptional activity. May function in the RHOA-DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a regulator of cell migration. The encoded protein appears to function in the RhoA (ras homolog gene family, member A)-Dia1 (diaphanous homolog 1) signal transduction pathway. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]
Uniprot Description
SCAI: Tumor suppressor which functions to suppress MKL1- induced SRF transcriptional activity. May function in the RHOA- DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1. Belongs to the SCAI family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 9q33.3
Cellular Component: cytoplasm; integral to membrane; nuclear membrane; nucleoplasm; nucleus
Molecular Function: protein binding; transcription corepressor activity
Biological Process: negative regulation of cell migration; negative regulation of Rho protein signal transduction; regulation of transcription, DNA-dependent; transcription, DNA-dependent
Research Articles on SCAI
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Product Notes
The SCAI scai (Catalog #AAA4752242) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SCAI Rabbit pAb reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's SCAI can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FC/FACS). WB: 1:1000 IHC: 1:20 ICC/IF: 1:20 FC/FACS: 1:20. Researchers should empirically determine the suitability of the SCAI scai for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SCAI, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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