Rabbit SBDS Polyclonal Antibody | anti-SBDS antibody

SBDS Rabbit Polyclonal

Cat. Num. AAA7603850

• Gene Names: SBDS; SDS; SWDS; CGI-97
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: SBDS; Polyclonal Antibody; SBDS Rabbit Polyclonal; anti-SBDS antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 250

• Applicable Applications for anti-SBDS antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Shwachman-Bodian-Diamond syndrome
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human gastric cancer using MBS7603850 (SBDS antibody) at dilution of 1:50)

Western Blot (WB)

(HL-60 cells were subjected to SDS PAGE followed by western blot with MBS7603850 (SBDS antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 823673138
• NCBI GeneID: 51119
• Molecular Weight: 28,764 Da
• NCBI Official Full Name: SBDS, partial
• NCBI Official Synonym Full Names: SBDS ribosome assembly guanine nucleotide exchange factor
• NCBI Official Symbol: SBDS
• NCBI Official Synonym Symbols: SDS; SWDS; CGI-97
• NCBI Protein Information: ribosome maturation protein SBDS
• UniProt Protein Name: Ribosome maturation protein SBDS
• Protein Family: Ribosome maturation protein
• UniProt Gene Name: SBDS
• UniProt Entry Name: SBDS_HUMAN

NCBI Description

This gene encodes a member of a highly conserved protein family that exists from archaea to vertebrates and plants. The encoded protein may function in RNA metabolism. Mutations within this gene are associated with Shwachman-Bodian-Diamond syndrome. An alternative transcript has been described, but its biological nature has not been determined. This gene has a closely linked pseudogene that is distally located. [provided by RefSeq, Jul 2008]

Uniprot Description

SBDS: Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFTUD1, triggers the GTP- dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation. Defects in SBDS are the cause of Shwachman-Diamond syndrome (SDS). SDS is an autosomal recessive disorder characterized by pancreatic exocrine insufficiency, hematologic dysfunction, and skeletal abnormalities. Belongs to the SDO1/SBDS family.

Protein type: Nucleolus

Chromosomal Location of Human Ortholog: 7q11.21

Cellular Component: cytoplasm; nucleolus; nucleoplasm; nucleus; spindle pole

Molecular Function: microtubule binding; protein binding; ribosome binding; rRNA binding

Biological Process: bone marrow development; bone mineralization; cell proliferation; inner cell mass cell proliferation; leukocyte chemotaxis; mature ribosome assembly; mitotic spindle organization and biogenesis; rRNA processing

Disease: Aplastic Anemia; Shwachman-diamond Syndrome