Rabbit SARS-CoV/SARS-CoV-2 Spike RBD Polyclonal Antibody | anti-SARS-CoV/SARS-CoV-2 antibody
SARS-CoV/SARS-CoV-2 Spike RBD Antibody, Rabbit PAb, Antigen Affinity Purified
Reactivity
SARS
Applications
ELISA
Purity
Protein A & Antigen Affinity
Synonyms
SARS-CoV/SARS-CoV-2 Spike RBD; Polyclonal Antibody; SARS-CoV/SARS-CoV-2 Spike RBD Antibody; Rabbit PAb; Antigen Affinity Purified; Anti-coronavirus s1 Antibody; Anti-coronavirus s2 Antibody; Anti-coronavirus spike Antibody; Anti-cov spike Antibody; Anti-ncov RBD Antibody; Anti-ncov s1 Antibody; Anti-ncov s2 Antibody; Anti-ncov spike Antibody; Anti-novel coronavirus RBD Antibody; Anti-novel coronavirus s1 Antibody; Anti-novel coronavirus s2 Antibody; Anti-novel coronavirus spike Antibody; Anti-RBD Antibody; Anti-S1 Antibody; Anti-s2 Antibody; Anti-Spike RBD Antibody; anti-SARS-CoV/SARS-CoV-2 antibody
Host
Rabbit
Reactivity
SARS
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
SARS-CoV Spike/RBD
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid. 0.2um filtered solution in PBS
Applicable Applications for anti-SARS-CoV/SARS-CoV-2 antibody
ELISA (EIA)
Application Notes
ELISA: 1:5000-1:10,000
Antibody's applications haven't been validated with corresponding virus positive samples.
Antibody's applications haven't been validated with corresponding virus positive samples.
Immunogen
Recombinant SARS-CoV Spike/RBD Protein
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with purified, recombinant SARS-CoV Spike/RBD. SARS-CoV Spike RBD specific IgG was purified by SARS-CoV Spike/RBD affinity chromatography.
Cross-reactivity
Has cross-reactivity in ELISA with
SARS-CoV Spike/S1
SARS-CoV-2 (2019-nCoV) Spike S1
SARS-CoV-2 (2019-nCoV) Spike RBD
SARS-CoV Spike/S1
SARS-CoV-2 (2019-nCoV) Spike S1
SARS-CoV-2 (2019-nCoV) Spike RBD
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Related Product Information for anti-SARS-CoV/SARS-CoV-2 antibody
Background: The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4; APN, aminopeptidase N; CEACAM, carcinoembryonic antigen-related cell adhesion molecule 1; Sia, sialic acid; O-ac Sia, O-acetylated sialic acid. The spike is essential for both host specificity and viral infectivity. The term 'peplomer' is typically used to refer to a grouping of heterologous proteins on the virus surface that function together. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. It's been reported that SARS-CoV-2 (COVID-19 coronavirus, 2019-nCoV) can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion; Defines the range of the hosts and specificity of the virus; Main component to bind with the neutralizing antibody; Key target for vaccine design; Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD), leading to a higher mortality rate.
References
Shen S, et al. (2007) Expression, glycosylation, and modification of the spike (S) glycoprotein of SARS CoV. Methods Mol Biol. 379: 127-35.Du L, et al. (2009) The spike protein of SARS-CoV--a target for vaccine and therapeutic development. Nat Rev Microbiol. 7 (3): 226-36.Xiao X, et al. (2004) The SARS-CoV S glycoprotein. Cell Mol Life Sci. 61 (19-20): 2428-30.
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Product Notes
The SARS-CoV/SARS-CoV-2 (Catalog #AAA8119487) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SARS-CoV/SARS-CoV-2 Spike RBD Antibody, Rabbit PAb, Antigen Affinity Purified reacts with SARS and may cross-react with other species as described in the data sheet. AAA Biotech's SARS-CoV/SARS-CoV-2 Spike RBD can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). ELISA: 1:5000-1:10,000 Antibody's applications haven't been validated with corresponding virus positive samples. Researchers should empirically determine the suitability of the SARS-CoV/SARS-CoV-2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SARS-CoV/SARS-CoV-2 Spike RBD, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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