Western Blot (WB)
(Host: RabbitTarget Name: SARDHSample Type: Jurkat Whole cell lysatesAntibody Dilution: 1.0ug/ml)
Rabbit SARDH Polyclonal Antibody | anti-SARDH antibody
SARDH Antibody - C-terminal region
Western Blot (WB)
(Host: RabbitTarget Name: SARDHSample Type: Jurkat Whole cell lysatesAntibody Dilution: 1.0ug/ml)
Western Blot (WB)
(Host: RabbitTarget Name: SARDHSample Type: Jurkat Whole cell lysatesAntibody Dilution: 1.0ug/ml)
Target Description: This gene encodes an enzyme localized to the mitochondrial matrix which catalyzes the oxidative demethylation of sarcosine. This enzyme is distinct from another mitochondrial matrix enzyme, dimethylglycine dehydrogenase, which catalyzes a reaction resulting in the formation of sarcosine. Mutations in this gene are associated with sarcosinemia. Alternatively spliced transcript variants have been described.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an enzyme localized to the mitochondrial matrix which catalyzes the oxidative demethylation of sarcosine. This enzyme is distinct from another mitochondrial matrix enzyme, dimethylglycine dehydrogenase, which catalyzes a reaction resulting in the formation of sarcosine. Mutations in this gene are associated with sarcosinemia. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2008]
Uniprot Description
SARDH: Defects in SARDH are a cause of sarcosinemia (SAR). Sarcosinemia is a metabolic disorder characterized by an increased concentration of sarcosine in plasma and urine due to sarcosine dehydrogenase deficiency. Prevalence has been estimated at 1:28'000 to 1:350'000 in newborn screening programs. Sarcosinemia is most probably a benign condition without significant clinical problems. It is transmitted in an autosomal recessive manner. Belongs to the GcvT family.
Protein type: Amino Acid Metabolism - glycine, serine and threonine; Oxidoreductase; EC 1.5.8.3; Mitochondrial
Chromosomal Location of Human Ortholog: 9q33-q34
Cellular Component: mitochondrion; mitochondrial matrix
Molecular Function: sarcosine dehydrogenase activity
Disease: Sarcosinemia
Research Articles on SARDH
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Product Notes
The SARDH sardh (Catalog #AAA3206321) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SARDH Antibody - C-terminal region reacts with Cow, Dog, Guinea Pig, Human, Mouse, Pig, Rabbit, Rat, Zebrafish and may cross-react with other species as described in the data sheet. AAA Biotech's SARDH can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the SARDH sardh for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: SLSIEKGYRH WHADLRPDDS PLEAGLAFTC KLKSPVPFLG REALEQQRAA. It is sometimes possible for the material contained within the vial of "SARDH, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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