Rabbit SAPAP2 Polyclonal Antibody | anti-DLGAP2 antibody

SAPAP2 Antibody

Cat. Num. AAA151501

• Gene Names: DLGAP2; DAP2; SAPAP2
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunofluorescence, Immunohistochemistry, Western Blot
• Purity: SAPAP2 Antibody is affinity chromatography purified via peptide column.
• Synonyms: SAPAP2; Polyclonal Antibody; SAPAP2 Antibody; DAP2; Disks large-associated protein 2; DAP-2; discs; large (Drosophila) homolog-associated protein 2; anti-DLGAP2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: At least three isoforms of SAPAP2 are known to exist. This SAPAP2 antibody will not cross-react with other SAPAP proteins.
• Purity/Purification: SAPAP2 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid; SAPAP2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 1054

• Applicable Applications for anti-DLGAP2 antibody: ELISA, IF, IHC-P, WB
• Application Notes: SAPAP2 antibody can be used for detection of SAPAP2 by Western blot at 0.5-1 ug/mL .; ; Antibody can also be used for immunohistochemistry starting at 5 ug/mL. ; ; For immunofluorescence start at 20 ug/mL. ; ; Optimal dilutions for each application to be determined by the researcher.
• Conjugate: Unconjugated
• Immunogen: SAPAP2 antibody was raised against a 16 amino acid synthetic peptide from near the center of human SAPAP2.; ; The immunogen is located within amino acids 480-530 of SAPAP2
• Positive control: MBS151628- Raji Cell Lysate; MBS154323- Human Brain Tissue Slide
• Preparation and Storage: SAPAP2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(SAPAP2 Antibody)

Immunohistochemistry (IHC)

(Immunohistochemistry of SAPAP2 in human brain with SAPAP2 antibody at 5 μg/mL.)

Immunofluorescence (IF)

(Immunofluorescence of SAPAP2 in Human Brain cells with SAPAP2 antibody at 20 μg/mL.)

Related Product Information for anti-DLGAP2 antibody

SAPAP2 Antibody: SAP90/PSD-95-associated protein 2 (SAPAP2, also known as DLGAP2) is a member of a protein family whose members specifically interact with PSD-95/SAP90, a membrane-associated guanylate kinase localized at postsynaptic density (PSD) in neuronal cells. Like the other SAPAP proteins, SAPAP2 is thought to be an adaptor protein that also interacts with different synaptic scaffolding proteins, cytoskeletal and signaling components, such as focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2). SAPAP2 mRNA is targeted to cell bodies in a similar manner to SAPAP1 and -4, whereas SAPAP3 mRNA is detected mainly in cell bodies.

NCBI and Uniprot Product Information

• NCBI GI #: 160395585
• NCBI GeneID: 9228
• UniProt Accession #: Q9P1A6; O14488; O14664; Q9P1A7; A1QCF8; A1QCF9; A5D8Y2
• Molecular Weight: Predicted :43 kDa; Observed: 52 kDa
• NCBI Official Full Name: Disks large-associated protein 2
• NCBI Official Synonym Full Names: discs, large (Drosophila) homolog-associated protein 2
• NCBI Official Symbol: DLGAP2
• NCBI Official Synonym Symbols: DAP2; SAPAP2
• NCBI Protein Information: disks large-associated protein 2; PSD-95/SAP90-binding protein 2; discs large-associated protein 2; SAP90/PSD-95-associated protein 2
• UniProt Protein Name: Disks large-associated protein 2
• Protein Family: Disks large-associated protein
• UniProt Gene Name: DLGAP2
• UniProt Synonym Gene Names: DAP2; DAP-2; SAPAP2
• UniProt Entry Name: DLGP2_HUMAN

NCBI Description

The product of this gene is a membrane-associated protein that may play a role in synapse organization and signalling in neuronal cells. This gene is biallelically expressed in the brain, however, only the paternal allele is expressed in the testis (PMID:18055845). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2014]

Uniprot Description

SAPAP2: May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. Belongs to the SAPAP family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Kinase, other

Chromosomal Location of Human Ortholog: 8p23

Cellular Component: postsynaptic membrane; postsynaptic density; neurofilament; cell junction

Molecular Function: protein binding

Biological Process: nerve-nerve synaptic transmission