Rabbit S2P Polyclonal Antibody | anti-MBTPS2 antibody

S2P Antibody

Cat. Num. AAA9629200

• Gene Names: MBTPS2; S2P; IFAP; KFSDX; BRESEK
• Reactivity: Human, Mouse, Rat
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: S2P; Polyclonal Antibody; S2P Antibody; BRESEK; Endopeptidase S2P; IFAP; KFSDX; MBTP2_HUMAN; MBTPS2; Membrane bound transcription factor site 2 protease; membrane-bound transcription factor peptidase; site 2; membrane-bound transcription factor protease; Membrane-bound transcription factor site-2 protease; S2P endopeptidase; Site 2 protease; SREBPs intramembrane protease; Sterol regulatory element-binding proteins intramembrane protease; anti-MBTPS2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: S2P Antibody detects endogenous levels of total S2P.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-MBTPS2 antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from Human MYOCD.
• Conjugation: Unconjugated
• Similarity: Belongs to the peptidase M50A family.
• Tissue Specificity: Expressed in heart, brain, placenta, lung, liver, muscle, kidney and pancreas.
• Function: Involved in regulated intramembrane proteolysis (RIP) that is the cleavage of membrane-spanning regulatory proteins by proteases within the plane of the membrane. It cleaves sterol-regulatory element-binding proteins (SREBPs) within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Mature N-terminal fragments shuttle to the nucleus and activate gene transcription. Involved in RIP-mediated regulation of bone formation.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-MBTPS2 antibody

Membrane; Multi-pass membrane protein; Cytoplasm; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 7706693
• NCBI GeneID: 51360
• NCBI Accession #: NP_056968.1
• NCBI GenBank Nucleotide #: NM_015884.3
• UniProt Accession #: O43462; Q9UM70; Q9UMD3
• Molecular Weight: 57,444 Da
• NCBI Official Full Name: membrane-bound transcription factor site-2 protease
• NCBI Official Synonym Full Names: membrane-bound transcription factor peptidase, site 2
• NCBI Official Symbol: MBTPS2
• NCBI Official Synonym Symbols: S2P; IFAP; KFSDX; BRESEK
• NCBI Protein Information: membrane-bound transcription factor site-2 protease; endopeptidase S2P; SREBPs intramembrane protease; membrane-bound transcription factor protease, site 2; sterol regulatory element-binding proteins intramembrane protease
• UniProt Protein Name: Membrane-bound transcription factor site-2 protease
• Protein Family: Membrane-bound transcription factor site-2 protease
• UniProt Gene Name: MBTPS2
• UniProt Synonym Gene Names: S2P; SREBPs intramembrane protease
• UniProt Entry Name: MBTP2_HUMAN

NCBI Description

This gene encodes a intramembrane zinc metalloprotease, which is essential in development. This protease functions in the signal protein activation involved in sterol control of transcription and the ER stress response. Mutations in this gene have been associated with ichthyosis follicularis with atrichia and photophobia (IFAP syndrome); IFAP syndrome has been quantitatively linked to a reduction in cholesterol homeostasis and ER stress response.[provided by RefSeq, Aug 2009]

Uniprot Description

MBTPS2: Intramembrane proteolysis of sterol-regulatory element- binding proteins (SREBPs) within the first transmembrane segment thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Site-2 cleavage comes after site-1 cleavage which takes place in the lumenal loop. Expressed in heart, brain, placenta, lung, liver, muscle, kidney and pancreas. Belongs to the peptidase M50A family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Protease; EC 3.4.24.85

Chromosomal Location of Human Ortholog: Xp22.12-p22.11

Cellular Component: Golgi membrane; cytoplasm; integral to membrane

Molecular Function: metalloendopeptidase activity; metal ion binding

Biological Process: cholesterol metabolic process; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; membrane protein intracellular domain proteolysis; unfolded protein response; positive regulation of transcription factor activity

Disease: Ifap Syndrome With Or Without Bresheck Syndrome; Palmoplantar Keratoderma, Mutilating, With Periorificial Keratotic Plaques, X-linked; Keratosis Follicularis Spinulosa Decalvans, X-linked