S100B Polyclonal Antibody | anti-S100B antibody

S100B

Cat. Num. AAA340398

• Gene Names: S100B; NEF; S100; S100-B; S100beta
• Applications: immunoassay
• Purity: Salt fractionation
• Synonyms: S100B; Polyclonal Antibody; S100-B; Protein S100-B; S100 calcium-binding protein B; S-100 protein subunit beta; S-100 protein beta chain; anti-S100B antibody

• Host: Ovis aries (Sheep)
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Salt fractionation
• Form/Format: Clear liquid - 20mM Phosphate, 150mM Sodium Chloride
• Concentration: 10.7 mg/mL (U.V.abs @ 280nm) (varies by lot)
• Sequence Length: 92

• Applicable Applications for anti-S100B antibody: The antibody is suitable for the development of immunoassays or immunoaffinity purification columns.
• Immunogen: Recombinant Human S100B
• Host Breed: Texel
• Preservative: 0.09% Sodium Azide
• pH: 7.4
• Assessment Method: Competitive ELISA (EIA)
• Preparation and Storage: Can be stored at +2°C-+8°C.; For long term storage, aliquot and store at <°C.; Avoid repeated freeze/thaw cycles.; Product should be protected from light exposure.

Related Product Information for anti-S100B antibody

The S100 family of proteins contain two EF-hand calcium-binding motifs and are thought to be involved in the regulation of a number of cellular processes including cell cycle progression and differentiation. Recombinant human S100A10 is expressed in E Coli with an amino-terminal hexa-histidine tag. This product is for research use only.

Product Categories/Family for anti-S100B antibody

Polyclonal Antibodies; Biochemical Markers; Proteins; S100 Beta Chain

References

Kondo A. et al. (2002) Acta Med. 56(1): 31-34.

NCBI and Uniprot Product Information

• NCBI GI #: 49457242
• NCBI GeneID: 6285
• UniProt Accession #: P04271; D3DSN6
• NCBI Official Full Name: S100B
• NCBI Official Synonym Full Names: S100 calcium binding protein B
• NCBI Official Symbol: S100B
• NCBI Official Synonym Symbols: NEF; S100; S100-B; S100beta
• NCBI Protein Information: protein S100-B
• UniProt Protein Name: Protein S100-B
• Protein Family: Protein
• UniProt Gene Name: S100B
• UniProt Entry Name: S100B_HUMAN

NCBI Description

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes. [provided by RefSeq, Jul 2008]

Uniprot Description

S100B: Weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain. The S100B dimer binds two molecules of STK38. Interacts with AGER. The S100B dimer interacts with two molecules of CAPZA1. Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues. Belongs to the S-101 family.

Protein type: Calcium-binding

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: cytoplasm; extracellular region; intracellular membrane-bound organelle; nucleus; perinuclear region of cytoplasm; ruffle

Molecular Function: calcium-dependent protein binding; identical protein binding; protein binding; protein homodimerization activity; RAGE receptor binding; tau protein binding; zinc ion binding

Biological Process: axonogenesis; cell proliferation; central nervous system development; innate immune response; learning and/or memory; positive regulation of I-kappaB kinase/NF-kappaB cascade