Rabbit anti-Human S100A13 Polyclonal Antibody | anti-S100A13 antibody
S100A13 Antibody
IHC: 1:25-1:100
Immunohistochemistry (IHC)-Paraffin
(The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using MBS7129662(S100A13 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200))
Immunohistochemistry (IHC)-Paraffin
(The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using MBS7129662(S100A13 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200))
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is widely expressed in various types of tissues with a high expression level in thyroid gland. In smooth muscle cells, this protein co-expresses with other family members in the nucleus and in stress fibers, suggesting diverse functions in signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
S100A13: Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine. Belongs to the S-100 family.
Chromosomal Location of Human Ortholog: 1q21
Cellular Component: extracellular space; mast cell granule; perinuclear region of cytoplasm; cytoplasm; nucleus; cytosol
Molecular Function: protein binding; RAGE receptor binding; fibroblast growth factor binding; copper ion binding; protein homodimerization activity; zinc ion binding; calcium ion binding; lipid binding
Biological Process: regulation of cell shape; positive regulation of I-kappaB kinase/NF-kappaB cascade; response to copper ion; interleukin-1 alpha secretion; positive regulation of cell proliferation; mast cell degranulation; response to electrical stimulus; cytokine secretion
