Sheep anti-Human S100 Calcium Binding Protein A11 Polyclonal Antibody | anti-S100A11 antibody
S100 Calcium Binding Protein A11 (S100A11)
Purified
Purified
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. [provided by RefSeq]
Uniprot Description
S100A11: a calcium-binding regulatory protein of the S-100 family. Interacts with the N-termini of annexins A1. May regulate fusion processes such as endo- and exocytosis. Increases in the early stage of pancreatic carcinogenesis and decreases during subsequent progression to cancer. Increased expression in anaplastic large cell lymphoma.
Protein type: Calcium-binding; DNA replication; Cell cycle regulation
Chromosomal Location of Human Ortholog: 1q21
Cellular Component: nucleoplasm; ruffle; extracellular space; cytoplasm; nucleus
Molecular Function: protein binding; protein homodimerization activity; calcium ion binding; calcium-dependent protein binding
Biological Process: negative regulation of cell proliferation; negative regulation of DNA replication; signal transduction
Research Articles on S100A11
2. Inhibition of S100A11 gene expression impairs the ability of keratinocytes to control vaccinia virus replication via downregulation of IFN-lambda receptor IL-10R2.
3. S100A11 targets Rad54B to sites of DNA DSB repair sites and has a role in p21-based regulation of cell cycle
4. These results identify two categories of S100 proteins: those exemplified by S100A4 that exclusively bind to the p53 TET domain; and those exemplified by S100B that additionally bind to the NRD.
5. S100A11 differentially expressed in primary hepatocellular carcinoma , primary colorectal, and liver
6. Phosphorylation of S100A11 induces a structural perturbation in the N-terminal edge of helix 1 and enables the phosphoryl group to be exposed to the solvent, allowing it to be recognized by the binding partner, nucleolin.
7. These findings indicate that S100A11 plays a dual role in growth regulation of epithelial cells.
8. S100/A11 and p21 gene expression was also found to be significantly lower in acute and chronic atopic dermatitis skin.
9. Following transformation by transglutaminase 2, S100A11 acquires the capacity to signal through the p38 MAP kinase pathway, accelerate chondrocyte hypertrophy, and couple inflammation with chondrocyte activation to promote progression of osteoarthritis.
10. These findings suggest S100A11 could be helpful in the pathological study of colorectal cancer, especially for the classification of different stages in colorectal cancer.
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Product Notes
The S100A11 s100a11 (Catalog #AAA620604) is an Antibody produced from Sheep and is intended for research purposes only. The product is available for immediate purchase. The S100 Calcium Binding Protein A11 (S100A11) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's S100 Calcium Binding Protein A11 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Gel Shift Assay (GS/EMSA). Suitable for use in ELISA, Western Blot, Dot Blot, Immunohistochemistry, Immunoassays, development of rapid tests and other antibody recognition assays. Researchers should empirically determine the suitability of the S100A11 s100a11 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "S100 Calcium Binding Protein A11, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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