Immunohistochemistry (IHC)
(Immunochemical staining of human RTN4 in human testis with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.)
Rabbit anti-Human RTN4 Polyclonal Antibody | anti-RTN4 antibody
Anti-RTN4 Antibody, Rabbit Polyclonal
Reactivity
Human
Applications
Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
RTN4; Polyclonal Antibody; Anti-RTN4 Antibody; Rabbit Polyclonal; RTN4 Antibody; Rabbit PAb; Antigen Affinity Purified; reticulon 4; Anti-ASY Antibody; Anti-DGU Antibody; Anti-DKFZp781L1143 Antibody; Anti-HIGM4 Antibody; Anti-Nbla00271 Antibody; Anti-Nbla10545 Antibody; Anti-NI220/250 Antibody; Anti-NOGO Antibody; Anti-NOGO-A Antibody; Anti-Nogo-B Antibody; Anti-Nogo-C Antibody; Anti-NOGOC Antibody; Anti-NSP Antibody; Anti-NSP-CL Antibody; Anti-RTN-X Antibody; Anti-RTN4-A Antibody; Anti-RTN4-B1 Antibody; Anti-RTN4-B2 Antibody; Anti-RTN4-C Antibody; Anti-UDG Antibody; Anti-UNG1 Antibody; Anti-UNG15 Antibody; Anti-UNG2 Antibody; anti-RTN4 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human RTN4
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; PBS, pH7.0 with 0.03% Proclin300
Applicable Applications for anti-RTN4 antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes
IHC-P: 1:300-1:2000
Immunogen
E Coli-derived Human RTN4 fragment
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with E Coli-derived Human RTN4 fragment, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining of human RTN4 in human testis with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human RTN4 in human testis with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.)
Related Product Information for anti-RTN4 antibody
Reticulon-4, also known as Foocen, Neurite outgrowth inhibitor, Nogo protein, Neuroendocrine-specific protein, Neuroendocrine-specific protein C homolog, RTN-x, Reticulon-5 and RTN4, is a multi-pass membrane protein that contains one reticulon domain. Isoform 1 of RTN4 is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform 2 of RTN4 is widely expressed except for the liver. Isoform 3 of RTN4 is expressed in brain, skeletal muscle and adipocytes. Isoform 4 of RTN4 is testis-specific. Reticulon-4/RTN4 is a developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Reticulon-4/RTN4 regulates neurite fasciculation, branching and extension in the developing nervous system. Reticulon-4/RTN4 is involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. It regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex. Isoform 2 of RTN4 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 of RTN4 inhibit BACE1 activity and amyloid precursor protein processing.
References
Yang J., et al., 2000, Cytogenet. Cell Genet. 88:101-102. Prinjha R., et al., 2000, Nature 403: 383-384. Tagami S., et al., 2000, Oncogene 19: 5736-5746. Murayama K.S., et al., 2006, Eur. J. Neurosci. 24: 1237-1244. Daub H., et al., 2008, Mol. Cell 31:438-448. Choudhary C., et al., 2009, Science 325: 834-840.
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Product Notes
The RTN4 (Catalog #AAA8110346) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-RTN4 Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's RTN4 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P). IHC-P: 1:300-1:2000. Researchers should empirically determine the suitability of the RTN4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RTN4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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