Rabbit RSPH9 Polyclonal Antibody | anti-RSPH9 antibody

RSPH9 Rabbit Polyclonal

Cat. Num. AAA7603743

• Gene Names: RSPH9; CILD12; C6orf206; MRPS18AL1
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: RSPH9; Polyclonal Antibody; RSPH9 Rabbit Polyclonal; anti-RSPH9 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 306

• Applicable Applications for anti-RSPH9 antibody: ELISA (EIA), Western Blot (WB)
• Immunogen: Radial spoke head 9 homolog (Chlamydomonas)
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Western Blot (WB)

(mouse testis tissue were subjected to SDS PAGE followed by western blot with MBS7603743 (RSPH9 Antibody) at dilution of 1:600)

NCBI and Uniprot Product Information

• NCBI GI #: 301069351
• NCBI GeneID: 221421
• NCBI Accession #: NP_001180270.1
• NCBI GenBank Nucleotide #: NM_001193341.1
• Molecular Weight: 34,430 Da
• NCBI Official Full Name: radial spoke head protein 9 homolog isoform 2
• NCBI Official Synonym Full Names: radial spoke head 9 homolog
• NCBI Official Symbol: RSPH9
• NCBI Official Synonym Symbols: CILD12; C6orf206; MRPS18AL1
• NCBI Protein Information: radial spoke head protein 9 homolog
• UniProt Protein Name: Radial spoke head protein 9 homolog
• Protein Family: Radial spoke head protein
• UniProt Gene Name: RSPH9
• UniProt Synonym Gene Names: C6orf206; MRPS18AL1
• UniProt Entry Name: RSPH9_HUMAN

NCBI Description

This gene encodes a protein thought to be a component of the radial spoke head in motile cilia and flagella. Mutations in this gene are associated with primary ciliary dyskinesia 12. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010]

Uniprot Description

RSPH9: Probable component of the axonemal radial spoke head. Radial spokes are regularly spaced along cilia, sperm and flagella axonemes. They consist of a thin stalk, which is attached to a subfiber of the outer doublet microtubule, and a bulbous head, which is attached to the stalk and appears to interact with the projections from the central pair of microtubules. Defects in RSPH9 are the cause of primary ciliary dyskinesia type 12 (CILD12). CILD is an autosomal recessive disorder characterized by axonemal abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit situs inversus, due to dysfunction of monocilia at the embryonic node and randomization of left-right body asymmetry. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. Belongs to the flagellar radial spoke RSP9 family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 6p21.1

Cellular Component: axoneme; cytoplasm; cytoskeleton

Molecular Function: protein binding

Biological Process: axoneme biogenesis

Disease: Ciliary Dyskinesia, Primary, 12