Mouse anti-Human RRAGD Polyclonal Antibody | anti-RRAGD antibody

RRAGD (Ras-related GTP-binding Protein D, Rag D, RagD, bA11D8.2.1)

Cat. Num. AAA6009381

• Gene Names: RRAGD; RAGD; bA11D8.2.1
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: RRAGD; Polyclonal Antibody; RRAGD (Ras-related GTP-binding Protein D; Rag D; RagD; bA11D8.2.1); Anti -RRAGD (Ras-related GTP-binding Protein D; anti-RRAGD antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human RRAGD.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.
• Sequence: MSQVLGKPQPQDEDDAEEEEEEDELVGLADYGDGPDSSDADPDSGTEEGVLDFSDPFSTEVKPRILLMGLRRSGKSSIQKVVFHKMSPNETLFLESTNKICREDVSNSSFVNFQIWDFPGQIDFFDPTFDYEMIFRGTGALIFVIDSQDDYMEALARLHLTVTRAYKVNTDINFEVFIHKVDGLSDDHKIETQRDIHQRANDDLADAGLEKIHLSFYLTSIYDHSIFEAFSKVVQKLIPQLPTLENLLNIFISNSGIEKAFLFDVVSKIYIATDSTPVDMQTYELCCDMIDVVIDISCIYGLKEDGAGTPYDKESTAIIKLNNTTVLYLKEVTKFLALVCFVREESFERKGLIDYNFHCFRKAIHEVFEVRMKVVKSRKVQNRLQKKKRATPNGTPRVLL

• Applicable Applications for anti-RRAGD antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.
• Immunogen: Full length human RRAGD, aa1-400 (NP_067067.1).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of RRAGD expression in transfected 293T cell line using MBS6009381 Lane 1: RRAGD transfected lysate (44kD). Lane 2: Non-transfected lysate.)

Product Categories/Family for anti-RRAGD antibody

Antibodies; Abs to GTPase; Rab; Ras; Rho Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 11034847
• NCBI GeneID: 58528
• NCBI Accession #: NP_067067.1
• NCBI GenBank Nucleotide #: NM_021244.4
• UniProt Accession #: Q9NQL2; Q7L8F9; Q9NPG0; A8K184
• Molecular Weight: 45,588 Da
• NCBI Official Full Name: ras-related GTP-binding protein D
• NCBI Official Synonym Full Names: Ras-related GTP binding D
• NCBI Official Symbol: RRAGD
• NCBI Official Synonym Symbols: RAGD; bA11D8.2.1
• NCBI Protein Information: ras-related GTP-binding protein D; Rag D protein
• UniProt Protein Name: Ras-related GTP-binding protein D
• Protein Family: Ras-related GTP-binding protein
• UniProt Gene Name: RRAGD
• UniProt Synonym Gene Names: Rag D; RagD
• UniProt Entry Name: RRAGD_HUMAN

NCBI Description

RRAGD is a monomeric guanine nucleotide-binding protein, or G protein. By binding GTP or GDP, small G proteins act as molecular switches in numerous cell processes and signaling pathways.[supplied by OMIM, Apr 2004]

Uniprot Description

RRAGD: Has guanine nucleotide-binding activity but lacks intrinsic GTPase activity. Probably required for the amino acid- induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Forms a heterodimer with RRAGA in a sequence-independent manner. Binds GTP. Interacts with NOL8 and RRAGB. Belongs to the GTR/RAG GTP-binding protein family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: G protein regulator, misc.

Chromosomal Location of Human Ortholog: 6q15

Cellular Component: lysosome; cytoplasm; nucleus

Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding; protein heterodimerization activity

Biological Process: metabolic process; regulation of autophagy; cellular response to starvation; positive regulation of TOR signaling pathway