Rabbit RPS17 Polyclonal Antibody | anti-RPS17 antibody

RPS17 Antibody (Center)

Cat. Num. AAA9217194

• Gene Names: RPS17; S17; DBA4; RPS17L; RPS17L1; RPS17L2
• Reactivity: Human; Predicted Reactivity: Bovine, Chicken, Human, Mouse, Pig, Rat
• Applications: Western Blot, ELISA
• Synonyms: RPS17; Polyclonal Antibody; RPS17 Antibody (Center); 40S ribosomal protein S17; anti-RPS17 antibody

• Host: Rabbit
• Reactivity: Human; Predicted Reactivity: Bovine, Chicken, Human, Mouse, Pig, Rat
• Clonality: Polyclonal
• Isotype: Ig
• Specificity: This RPS17 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 55-87 amino acids from the Central region of human RPS17.
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Sequence Length: 135

• Applicable Applications for anti-RPS17 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB:~~1:2000
• Subtitle: Purified Rabbit Polyclonal Antibody (Pab)
• Antigen Type: Synthesized Peptide
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(All lanes : Anti-RPS17 Antibody (Center) at 1:2000 dilutionLane 1: Jurkat whole cell lysateLane 2: Hela whole cell lysateLane 3: MCF-7 whole cell lysateLane 4: HL-60 whole cell lysateLane 5: THP-1 whole cell lysateLane 6: NCI-H292 whole cell lysateLysates/proteins at 20 ug per lane. SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 16 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)

Product Categories/Family for anti-RPS17 antibody

Crown Antibodies; New Antibodies

References

Chen I.-T.,et al.Proc. Natl. Acad. Sci. U.S.A. 83:6907-6911 (1986). Chen I.-T.,et al.Gene 70:107-116 (1988). Ota T.,et al.Nat. Genet. 36:40-45 (2004). Zody M.C.,et al.Nature 440:671-675 (2006). Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

NCBI and Uniprot Product Information

• NCBI GI #: 4506693
• NCBI GeneID: 6218
• NCBI Accession #: NP_001012.1
• NCBI GenBank Nucleotide #: NM_001021.4
• UniProt Accession #: P08708; P0CW22; B2R4U4
• Molecular Weight: 15550 Da
• NCBI Official Full Name: 40S ribosomal protein S17
• NCBI Official Synonym Full Names: ribosomal protein S17
• NCBI Official Symbol: RPS17
• NCBI Official Synonym Symbols: S17; DBA4; RPS17L; RPS17L1; RPS17L2
• NCBI Protein Information: 40S ribosomal protein S17
• UniProt Protein Name: 40S ribosomal protein S17
• Protein Family: 40S ribosomal protein
• UniProt Gene Name: RPS17
• UniProt Entry Name: RS17_HUMAN

NCBI Description

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S17E family of ribosomal proteins and is located in the cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia 4. Alternative splicing of this gene results in multiple transcript variants. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Apr 2014]

Uniprot Description

RPS17: Defects in RPS17 are the cause of Diamond-Blackfan anemia type 4 (DBA4). DBA4 is a form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. Belongs to the ribosomal protein S17e family.

Protein type: Ribosomal; Translation

Chromosomal Location of Human Ortholog: 15q

Cellular Component: cytosol; focal adhesion; membrane; nucleoplasm; ribosome

Molecular Function: structural constituent of ribosome

Biological Process: erythrocyte homeostasis; mRNA catabolic process, nonsense-mediated decay; ribosomal small subunit assembly and maintenance; ribosomal small subunit biogenesis and assembly; rRNA processing; SRP-dependent cotranslational protein targeting to membrane; translation; translational initiation; viral transcription

Disease: Diamond-blackfan Anemia 4