Rabbit RPIA Polyclonal Antibody | anti-RPIA antibody

RPIA Rabbit Polyclonal

Cat. Num. AAA7603640

• Gene Names: RPIA; RPI; RPIAD
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunofluorescence
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: RPIA; Polyclonal Antibody; RPIA Rabbit Polyclonal; anti-RPIA antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 237

• Applicable Applications for anti-RPIA antibody: ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
• Immunogen: Ribose 5-phosphate isomerase A
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Western Blot (WB)

(mouse spleen tissue were subjected to SDS PAGE followed by western blot with MBS7603640 (RPIA antibody) at dilution of 1:1500)

NCBI and Uniprot Product Information

• NCBI GI #: 823669126
• NCBI GeneID: 22934
• Molecular Weight: 33,269 Da
• NCBI Official Full Name: RPIA, partial
• NCBI Official Synonym Full Names: ribose 5-phosphate isomerase A
• NCBI Official Symbol: RPIA
• NCBI Official Synonym Symbols: RPI; RPIAD
• NCBI Protein Information: ribose-5-phosphate isomerase
• UniProt Protein Name: Ribose-5-phosphate isomerase
• Protein Family: Ribose-5-phosphate isomerase
• UniProt Gene Name: RPIA
• UniProt Synonym Gene Names: RPI
• UniProt Entry Name: RPIA_HUMAN

NCBI Description

The protein encoded by this gene is an enzyme, which catalyzes the reversible conversion between ribose-5-phosphate and ribulose-5-phosphate in the pentose-phosphate pathway. This gene is highly conserved in most organisms. The enzyme plays an essential role in the carbohydrate metabolism. Mutations in this gene cause ribose 5-phosphate isomerase deficiency. A pseudogene is found on chromosome 18. [provided by RefSeq, Mar 2010]

Uniprot Description

RPIA: Defects in RPIA are the cause of ribose 5-phosphate isomerase deficiency (RPID). A patient has been described with a deficiency of ribose 5-phosphate isomerase who presented with leukoencephalopathy and peripheral neuropathy. Proton magnetic resonance spectroscopy of the brain revealed a highly elevated level of the polyols ribitol and D-arabitol, which were subsequently also found in high concentrations in body fluids. Deficient activity of RPIA, one of the pentose phosphate pathway enzymes, has been demonstrated in fibroblasts. Belongs to the ribose 5-phosphate isomerase family.

Protein type: Carbohydrate Metabolism - pentose phosphate pathway; EC 5.3.1.6; Isomerase

Chromosomal Location of Human Ortholog: 2p11.2

Cellular Component: cytosol; intracellular membrane-bound organelle

Molecular Function: monosaccharide binding; protein binding; ribose-5-phosphate isomerase activity

Biological Process: pentose-phosphate shunt; pentose-phosphate shunt, non-oxidative branch

Disease: Ribose 5-phosphate Isomerase Deficiency